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Gene: TXNL1 |
Gene summary for TXNL1 |
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Gene information | Species | Human | Gene symbol | TXNL1 | Gene ID | 9352 |
Gene name | thioredoxin like 1 | |
Gene Alias | HEL-S-114 | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000502 | UniProtAcc | O43396 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9352 | TXNL1 | LZE2D | Human | Esophagus | HGIN | 2.08e-02 | 9.04e-02 | 0.0642 |
9352 | TXNL1 | LZE4T | Human | Esophagus | ESCC | 2.35e-13 | 4.54e-01 | 0.0811 |
9352 | TXNL1 | LZE7T | Human | Esophagus | ESCC | 2.99e-09 | 1.13e+00 | 0.0667 |
9352 | TXNL1 | LZE8T | Human | Esophagus | ESCC | 1.41e-04 | 1.73e-01 | 0.067 |
9352 | TXNL1 | LZE20T | Human | Esophagus | ESCC | 1.70e-06 | -3.68e-02 | 0.0662 |
9352 | TXNL1 | LZE24T | Human | Esophagus | ESCC | 2.95e-16 | 6.39e-01 | 0.0596 |
9352 | TXNL1 | P1T-E | Human | Esophagus | ESCC | 5.82e-04 | 6.90e-01 | 0.0875 |
9352 | TXNL1 | P2T-E | Human | Esophagus | ESCC | 2.83e-60 | 1.13e+00 | 0.1177 |
9352 | TXNL1 | P4T-E | Human | Esophagus | ESCC | 2.50e-56 | 1.74e+00 | 0.1323 |
9352 | TXNL1 | P5T-E | Human | Esophagus | ESCC | 5.65e-23 | 5.27e-01 | 0.1327 |
9352 | TXNL1 | P8T-E | Human | Esophagus | ESCC | 3.40e-38 | 7.14e-01 | 0.0889 |
9352 | TXNL1 | P9T-E | Human | Esophagus | ESCC | 3.72e-16 | 6.34e-01 | 0.1131 |
9352 | TXNL1 | P10T-E | Human | Esophagus | ESCC | 7.38e-42 | 8.47e-01 | 0.116 |
9352 | TXNL1 | P11T-E | Human | Esophagus | ESCC | 2.23e-17 | 9.50e-01 | 0.1426 |
9352 | TXNL1 | P12T-E | Human | Esophagus | ESCC | 3.05e-36 | 8.23e-01 | 0.1122 |
9352 | TXNL1 | P15T-E | Human | Esophagus | ESCC | 1.25e-27 | 7.01e-01 | 0.1149 |
9352 | TXNL1 | P16T-E | Human | Esophagus | ESCC | 1.40e-31 | 8.23e-01 | 0.1153 |
9352 | TXNL1 | P17T-E | Human | Esophagus | ESCC | 2.89e-05 | 7.20e-01 | 0.1278 |
9352 | TXNL1 | P19T-E | Human | Esophagus | ESCC | 4.69e-09 | 1.37e+00 | 0.1662 |
9352 | TXNL1 | P20T-E | Human | Esophagus | ESCC | 1.97e-16 | 6.94e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNL1 | SNV | Missense_Mutation | novel | c.484N>A | p.Asp162Asn | p.D162N | O43396 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.659N>C | p.Leu220Pro | p.L220P | O43396 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TXNL1 | SNV | Missense_Mutation | c.585A>C | p.Lys195Asn | p.K195N | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TXNL1 | SNV | Missense_Mutation | novel | c.93N>A | p.Met31Ile | p.M31I | O43396 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | novel | c.839N>A | p.Arg280Gln | p.R280Q | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.585N>C | p.Lys195Asn | p.K195N | O43396 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TXNL1 | SNV | Missense_Mutation | rs745346344 | c.479N>G | p.Asp160Gly | p.D160G | O43396 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TXNL1 | SNV | Missense_Mutation | c.700N>T | p.Arg234Cys | p.R234C | O43396 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TXNL1 | deletion | Frame_Shift_Del | novel | c.482delG | p.Cys161LeufsTer20 | p.C161Lfs*20 | O43396 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TXNL1 | deletion | Frame_Shift_Del | c.855delA | p.Gly286GlufsTer23 | p.G286Efs*23 | O43396 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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