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Gene: TNFAIP8L1 |
Gene summary for TNFAIP8L1 |
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Gene information | Species | Human | Gene symbol | TNFAIP8L1 | Gene ID | 126282 |
Gene name | TNF alpha induced protein 8 like 1 | |
Gene Alias | TIPE1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q8WVP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126282 | TNFAIP8L1 | P9T-E | Human | Esophagus | ESCC | 2.56e-03 | 2.05e-01 | 0.1131 |
126282 | TNFAIP8L1 | P10T-E | Human | Esophagus | ESCC | 4.70e-03 | 1.73e-01 | 0.116 |
126282 | TNFAIP8L1 | P12T-E | Human | Esophagus | ESCC | 8.97e-03 | 8.47e-02 | 0.1122 |
126282 | TNFAIP8L1 | P17T-E | Human | Esophagus | ESCC | 6.58e-04 | 2.37e-01 | 0.1278 |
126282 | TNFAIP8L1 | P20T-E | Human | Esophagus | ESCC | 1.18e-04 | 1.92e-01 | 0.1124 |
126282 | TNFAIP8L1 | P21T-E | Human | Esophagus | ESCC | 1.81e-07 | 2.65e-01 | 0.1617 |
126282 | TNFAIP8L1 | P23T-E | Human | Esophagus | ESCC | 4.31e-03 | 1.90e-01 | 0.108 |
126282 | TNFAIP8L1 | P24T-E | Human | Esophagus | ESCC | 2.62e-04 | 1.94e-01 | 0.1287 |
126282 | TNFAIP8L1 | P28T-E | Human | Esophagus | ESCC | 1.83e-08 | 1.99e-01 | 0.1149 |
126282 | TNFAIP8L1 | P31T-E | Human | Esophagus | ESCC | 2.69e-03 | 1.73e-01 | 0.1251 |
126282 | TNFAIP8L1 | P32T-E | Human | Esophagus | ESCC | 1.66e-10 | 1.60e-01 | 0.1666 |
126282 | TNFAIP8L1 | P36T-E | Human | Esophagus | ESCC | 3.76e-02 | 1.81e-01 | 0.1187 |
126282 | TNFAIP8L1 | P37T-E | Human | Esophagus | ESCC | 4.12e-04 | 1.27e-01 | 0.1371 |
126282 | TNFAIP8L1 | P39T-E | Human | Esophagus | ESCC | 1.73e-02 | 3.86e-02 | 0.0894 |
126282 | TNFAIP8L1 | P42T-E | Human | Esophagus | ESCC | 3.45e-05 | 2.73e-01 | 0.1175 |
126282 | TNFAIP8L1 | P47T-E | Human | Esophagus | ESCC | 2.76e-03 | 7.84e-02 | 0.1067 |
126282 | TNFAIP8L1 | P52T-E | Human | Esophagus | ESCC | 2.78e-06 | 2.58e-01 | 0.1555 |
126282 | TNFAIP8L1 | P61T-E | Human | Esophagus | ESCC | 6.76e-04 | 1.33e-01 | 0.099 |
126282 | TNFAIP8L1 | P62T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.48e-01 | 0.1302 |
126282 | TNFAIP8L1 | P65T-E | Human | Esophagus | ESCC | 4.38e-02 | 4.74e-02 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00320061 | Esophagus | ESCC | regulation of TOR signaling | 63/8552 | 104/18723 | 1.55e-03 | 7.29e-03 | 63 |
GO:00319292 | Liver | Cirrhotic | TOR signaling | 44/4634 | 126/18723 | 6.69e-03 | 3.30e-02 | 44 |
GO:00319291 | Liver | HCC | TOR signaling | 78/7958 | 126/18723 | 8.49e-06 | 9.97e-05 | 78 |
GO:0032006 | Liver | HCC | regulation of TOR signaling | 63/7958 | 104/18723 | 1.50e-04 | 1.20e-03 | 63 |
GO:003192911 | Thyroid | ATC | TOR signaling | 59/6293 | 126/18723 | 1.39e-03 | 7.19e-03 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFAIP8L1 | insertion | Frame_Shift_Ins | novel | c.62_63insATTCTCCTGCCTCAGCCTCCCAAGTAGCGGGGATTGC | p.Met21IlefsTer25 | p.M21Ifs*25 | Q8WVP5 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TNFAIP8L1 | insertion | Nonsense_Mutation | novel | c.136_137insTTTTTTTTTTTTAGAGATAGGGTCTTGTTATGTTG | p.Thr46IlefsTer5 | p.T46Ifs*5 | Q8WVP5 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
TNFAIP8L1 | SNV | Missense_Mutation | c.109N>C | p.Glu37Gln | p.E37Q | Q8WVP5 | protein_coding | tolerated(0.07) | benign(0.033) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
TNFAIP8L1 | SNV | Missense_Mutation | novel | c.271N>T | p.Arg91Cys | p.R91C | Q8WVP5 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-JW-A5VH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
TNFAIP8L1 | SNV | Missense_Mutation | c.223N>T | p.Arg75Cys | p.R75C | Q8WVP5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNFAIP8L1 | SNV | Missense_Mutation | novel | c.190G>A | p.Val64Ile | p.V64I | Q8WVP5 | protein_coding | tolerated(1) | benign(0.012) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFAIP8L1 | SNV | Missense_Mutation | novel | c.272N>A | p.Arg91His | p.R91H | Q8WVP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFAIP8L1 | SNV | Missense_Mutation | novel | c.320N>C | p.Val107Ala | p.V107A | Q8WVP5 | protein_coding | deleterious(0) | possibly_damaging(0.553) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFAIP8L1 | SNV | Missense_Mutation | rs375118206 | c.224G>A | p.Arg75His | p.R75H | Q8WVP5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
TNFAIP8L1 | SNV | Missense_Mutation | novel | c.21N>T | p.Lys7Asn | p.K7N | Q8WVP5 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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