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Gene: TMEM208 |
Gene summary for TMEM208 |
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Gene information | Species | Human | Gene symbol | TMEM208 | Gene ID | 29100 |
Gene name | transmembrane protein 208 | |
Gene Alias | HSPC171 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | J3KRY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29100 | TMEM208 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.41e-08 | 3.48e-01 | -0.1808 |
29100 | TMEM208 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.70e-11 | 4.03e-01 | -0.0811 |
29100 | TMEM208 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.37e-07 | 2.31e-01 | -0.1954 |
29100 | TMEM208 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.18e-03 | 4.14e-01 | -0.2196 |
29100 | TMEM208 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.26e-03 | 1.97e-01 | -0.1207 |
29100 | TMEM208 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.94e-08 | 3.45e-01 | -0.1526 |
29100 | TMEM208 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.12e-16 | 3.86e-01 | -0.1464 |
29100 | TMEM208 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.73e-06 | 2.21e-01 | -0.1001 |
29100 | TMEM208 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.08e-16 | 5.15e-01 | -0.059 |
29100 | TMEM208 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.11e-11 | 2.38e-01 | 0.096 |
29100 | TMEM208 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.86e-02 | 1.16e-01 | 0.0338 |
29100 | TMEM208 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.75e-05 | 1.81e-01 | 0.0674 |
29100 | TMEM208 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.30e-02 | 3.71e-01 | 0.0112 |
29100 | TMEM208 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.87e-06 | 2.27e-01 | 0.0588 |
29100 | TMEM208 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.21e-06 | 1.95e-01 | 0.294 |
29100 | TMEM208 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.86e-10 | 4.81e-01 | 0.281 |
29100 | TMEM208 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.56e-21 | 5.11e-01 | 0.3859 |
29100 | TMEM208 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.65e-08 | 2.43e-01 | 0.3005 |
29100 | TMEM208 | LZE4T | Human | Esophagus | ESCC | 5.48e-19 | 6.54e-01 | 0.0811 |
29100 | TMEM208 | LZE7T | Human | Esophagus | ESCC | 9.15e-15 | 7.04e-01 | 0.0667 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
GO:00164852 | Colorectum | MSS | protein processing | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:00164857 | Esophagus | HGIN | protein processing | 49/2587 | 225/18723 | 7.04e-04 | 9.52e-03 | 49 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:001648513 | Oral cavity | LP | protein processing | 83/4623 | 225/18723 | 2.87e-05 | 4.52e-04 | 83 |
GO:00516049 | Prostate | BPH | protein maturation | 80/3107 | 294/18723 | 2.64e-06 | 4.23e-05 | 80 |
GO:00164855 | Prostate | BPH | protein processing | 62/3107 | 225/18723 | 2.22e-05 | 2.67e-04 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM208 | insertion | Frame_Shift_Ins | novel | c.389_390insCTGCTTGGTGACGAGGAGTGGTACCCGAAAAAGCTCTAGA | p.Gly131CysfsTer42 | p.G131Cfs*42 | Q9BTX3 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM208 | SNV | Missense_Mutation | c.98N>T | p.Ala33Val | p.A33V | Q9BTX3 | protein_coding | tolerated(0.15) | probably_damaging(0.985) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM208 | SNV | Missense_Mutation | novel | c.75N>A | p.Phe25Leu | p.F25L | Q9BTX3 | protein_coding | deleterious(0.04) | probably_damaging(0.952) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM208 | SNV | Missense_Mutation | rs749211328 | c.179N>A | p.Ser60Asn | p.S60N | Q9BTX3 | protein_coding | deleterious(0.01) | possibly_damaging(0.773) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM208 | SNV | Missense_Mutation | novel | c.37N>G | p.Lys13Glu | p.K13E | Q9BTX3 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM208 | SNV | Missense_Mutation | novel | c.317N>C | p.Ile106Thr | p.I106T | Q9BTX3 | protein_coding | deleterious(0) | possibly_damaging(0.824) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
TMEM208 | SNV | Missense_Mutation | novel | c.328N>T | p.Ala110Ser | p.A110S | Q9BTX3 | protein_coding | tolerated(0.63) | probably_damaging(0.986) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM208 | SNV | Missense_Mutation | novel | c.122N>T | p.Thr41Met | p.T41M | Q9BTX3 | protein_coding | tolerated(0.48) | benign(0.093) | TCGA-EY-A1GX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TMEM208 | SNV | Missense_Mutation | rs773193944 | c.499N>T | p.Arg167Trp | p.R167W | Q9BTX3 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM208 | SNV | Missense_Mutation | rs367799210 | c.205N>T | p.His69Tyr | p.H69Y | Q9BTX3 | protein_coding | tolerated(0.06) | benign(0.014) | TCGA-97-7941-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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