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Gene: TEX30 |
Gene summary for TEX30 |
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Gene information | Species | Human | Gene symbol | TEX30 | Gene ID | 93081 |
Gene name | testis expressed 30 | |
Gene Alias | C13orf27 | |
Cytomap | 13q33.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5JUR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93081 | TEX30 | LZE7T | Human | Esophagus | ESCC | 1.67e-02 | 2.12e-01 | 0.0667 |
93081 | TEX30 | LZE8T | Human | Esophagus | ESCC | 1.99e-02 | 2.07e-01 | 0.067 |
93081 | TEX30 | LZE22T | Human | Esophagus | ESCC | 1.27e-02 | 2.99e-01 | 0.068 |
93081 | TEX30 | LZE24T | Human | Esophagus | ESCC | 2.73e-03 | 1.41e-01 | 0.0596 |
93081 | TEX30 | P2T-E | Human | Esophagus | ESCC | 1.66e-14 | 3.12e-01 | 0.1177 |
93081 | TEX30 | P4T-E | Human | Esophagus | ESCC | 1.67e-13 | 3.67e-01 | 0.1323 |
93081 | TEX30 | P5T-E | Human | Esophagus | ESCC | 1.52e-15 | 2.39e-01 | 0.1327 |
93081 | TEX30 | P8T-E | Human | Esophagus | ESCC | 1.99e-06 | 2.86e-01 | 0.0889 |
93081 | TEX30 | P9T-E | Human | Esophagus | ESCC | 2.71e-07 | 2.41e-01 | 0.1131 |
93081 | TEX30 | P10T-E | Human | Esophagus | ESCC | 9.39e-19 | 3.48e-01 | 0.116 |
93081 | TEX30 | P11T-E | Human | Esophagus | ESCC | 1.08e-06 | 2.85e-01 | 0.1426 |
93081 | TEX30 | P12T-E | Human | Esophagus | ESCC | 8.78e-18 | 4.04e-01 | 0.1122 |
93081 | TEX30 | P15T-E | Human | Esophagus | ESCC | 2.41e-06 | 2.10e-01 | 0.1149 |
93081 | TEX30 | P16T-E | Human | Esophagus | ESCC | 1.27e-12 | 3.67e-01 | 0.1153 |
93081 | TEX30 | P17T-E | Human | Esophagus | ESCC | 6.17e-04 | 2.92e-01 | 0.1278 |
93081 | TEX30 | P19T-E | Human | Esophagus | ESCC | 1.12e-04 | 4.26e-01 | 0.1662 |
93081 | TEX30 | P20T-E | Human | Esophagus | ESCC | 2.83e-04 | 1.83e-01 | 0.1124 |
93081 | TEX30 | P21T-E | Human | Esophagus | ESCC | 8.09e-14 | 3.86e-01 | 0.1617 |
93081 | TEX30 | P22T-E | Human | Esophagus | ESCC | 4.51e-08 | 1.03e-01 | 0.1236 |
93081 | TEX30 | P23T-E | Human | Esophagus | ESCC | 1.84e-09 | 3.45e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEX30 | SNV | Missense_Mutation | c.169C>T | p.His57Tyr | p.H57Y | Q5JUR7 | protein_coding | tolerated(0.07) | benign(0.206) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
TEX30 | deletion | Frame_Shift_Del | novel | c.186delN | p.Arg63AspfsTer20 | p.R63Dfs*20 | Q5JUR7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TEX30 | SNV | Missense_Mutation | novel | c.56C>T | p.Ala19Val | p.A19V | Q5JUR7 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TEX30 | SNV | Missense_Mutation | novel | c.657N>G | p.Ile219Met | p.I219M | Q5JUR7 | protein_coding | tolerated(0.14) | benign(0.216) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TEX30 | SNV | Missense_Mutation | rs199524126 | c.373N>T | p.Arg125Trp | p.R125W | Q5JUR7 | protein_coding | deleterious(0.02) | possibly_damaging(0.744) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TEX30 | SNV | Missense_Mutation | c.427N>T | p.Leu143Phe | p.L143F | Q5JUR7 | protein_coding | tolerated(0.09) | possibly_damaging(0.9) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TEX30 | SNV | Missense_Mutation | novel | c.43N>G | p.Lys15Glu | p.K15E | Q5JUR7 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEX30 | SNV | Missense_Mutation | novel | c.542N>T | p.Pro181Leu | p.P181L | Q5JUR7 | protein_coding | tolerated(0.08) | possibly_damaging(0.815) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEX30 | SNV | Missense_Mutation | rs767857286 | c.302N>A | p.Arg101His | p.R101H | Q5JUR7 | protein_coding | deleterious(0) | possibly_damaging(0.766) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEX30 | SNV | Missense_Mutation | rs199524126 | c.373N>T | p.Arg125Trp | p.R125W | Q5JUR7 | protein_coding | deleterious(0.02) | possibly_damaging(0.744) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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