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Gene: STRIP2 |
Gene summary for STRIP2 |
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Gene information | Species | Human | Gene symbol | STRIP2 | Gene ID | 57464 |
Gene name | striatin interacting protein 2 | |
Gene Alias | FAM40B | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9ULQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57464 | STRIP2 | ATC09 | Human | Thyroid | ATC | 1.29e-03 | 2.02e-01 | 0.2871 |
57464 | STRIP2 | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 2.16e-01 | 0.34 |
57464 | STRIP2 | ATC1 | Human | Thyroid | ATC | 1.55e-03 | 2.19e-01 | 0.2878 |
57464 | STRIP2 | ATC2 | Human | Thyroid | ATC | 9.20e-14 | 8.26e-01 | 0.34 |
57464 | STRIP2 | ATC4 | Human | Thyroid | ATC | 6.40e-11 | 2.85e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:000836026 | Thyroid | ATC | regulation of cell shape | 91/6293 | 154/18723 | 7.33e-11 | 2.31e-09 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STRIP2 | SNV | Missense_Mutation | novel | c.1553N>G | p.Ile518Ser | p.I518S | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | novel | c.1092N>G | p.Phe364Leu | p.F364L | Q9ULQ0 | protein_coding | tolerated(0.45) | benign(0.404) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STRIP2 | insertion | Frame_Shift_Ins | novel | c.973_974insTGAGTGGGGCTAACTATGGGCTTGGAACAGGGCAGATGATTAGC | p.Asp325ValfsTer80 | p.D325Vfs*80 | Q9ULQ0 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
STRIP2 | SNV | Missense_Mutation | novel | c.425G>A | p.Cys142Tyr | p.C142Y | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STRIP2 | SNV | Missense_Mutation | novel | c.788A>C | p.His263Pro | p.H263P | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STRIP2 | SNV | Missense_Mutation | rs778667266 | c.683N>A | p.Arg228Gln | p.R228Q | Q9ULQ0 | protein_coding | tolerated(0.08) | probably_damaging(0.992) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
STRIP2 | SNV | Missense_Mutation | rs372192438 | c.2225N>A | p.Arg742His | p.R742H | Q9ULQ0 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
STRIP2 | SNV | Missense_Mutation | rs772928723 | c.2333N>A | p.Arg778His | p.R778H | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | novel | c.913N>A | p.Glu305Lys | p.E305K | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
STRIP2 | SNV | Missense_Mutation | rs760234230 | c.2086C>T | p.Arg696Trp | p.R696W | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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