GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000170118 | Esophagus | HGIN | in utero embryonic development | 77/2587 | 367/18723 | 9.56e-05 | 2.05e-03 | 77 |
GO:000189019 | Esophagus | HGIN | placenta development | 35/2587 | 144/18723 | 5.02e-04 | 7.31e-03 | 35 |
GO:000189218 | Esophagus | HGIN | embryonic placenta development | 23/2587 | 82/18723 | 5.47e-04 | 7.73e-03 | 23 |
GO:00605379 | Esophagus | HGIN | muscle tissue development | 76/2587 | 403/18723 | 2.67e-03 | 2.63e-02 | 76 |
GO:00147068 | Esophagus | HGIN | striated muscle tissue development | 72/2587 | 384/18723 | 3.94e-03 | 3.56e-02 | 72 |
GO:006145819 | Esophagus | HGIN | reproductive system development | 78/2587 | 427/18723 | 5.53e-03 | 4.52e-02 | 78 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:0001890110 | Esophagus | ESCC | placenta development | 98/8552 | 144/18723 | 4.46e-08 | 8.11e-07 | 98 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
GO:00900689 | Esophagus | ESCC | positive regulation of cell cycle process | 142/8552 | 236/18723 | 4.79e-06 | 5.08e-05 | 142 |
GO:000189219 | Esophagus | ESCC | embryonic placenta development | 57/8552 | 82/18723 | 1.06e-05 | 1.01e-04 | 57 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00454454 | Esophagus | ESCC | myoblast differentiation | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
GO:00607065 | Esophagus | ESCC | cell differentiation involved in embryonic placenta development | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SOX15 | INCAF | Endometrium | EEC | SIAH2,PENK,DPT, etc. | 4.02e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
SOX15 | CD8TRM | Esophagus | ESCC | SHISA2,CASP6,NECAB3, etc. | 5.08e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
SOX15 | MSC | Esophagus | ESCC | C7,SCN7A,ABCA8, etc. | 2.62e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
SOX15 | MSC.MVA | Oral cavity | OSCC | AKR1C2,KRT5,C19orf33, etc. | 2.84e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_OSCC/regulons_activity_in_dotplot.png) |
SOX15 | STM | Prostate | ADJ | SERPINB5,GJB5,MYH11, etc. | 4.41e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
SOX15 | STM | Prostate | Tumor | SERPINB5,GJB5,MYH11, etc. | 1.97e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Tumor/regulons_activity_in_dotplot.png) |
SOX15 | URO | Prostate | Tumor | SERPINB5,GJB5,MYH11, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Prostate/Str/TF_Tumor/regulons_activity_in_dotplot.png) |
SOX15 | INMON | Skin | ADJ | RIN1,GJB2,HOPX, etc. | 1.99e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
SOX15 | CD8TRM | Skin | AK | RIN1,GJB2,HOPX, etc. | 3.30e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Skin/Str/TF_AK/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX15 | SNV | Missense_Mutation | | c.38N>T | p.Ser13Ile | p.S13I | O60248 | protein_coding | deleterious_low_confidence(0) | benign(0.125) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | | SD |
SOX15 | SNV | Missense_Mutation | novel | c.168C>G | p.Phe56Leu | p.F56L | O60248 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-S3-AA15-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SOX15 | deletion | Frame_Shift_Del | novel | c.252delN | p.Ala85ArgfsTer146 | p.A85Rfs*146 | O60248 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SOX15 | SNV | Missense_Mutation | rs755842358 | c.623N>T | p.Thr208Ile | p.T208I | O60248 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SOX15 | SNV | Missense_Mutation | | c.413N>A | p.Arg138Lys | p.R138K | O60248 | protein_coding | tolerated_low_confidence(0.81) | benign(0.01) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SOX15 | SNV | Missense_Mutation | | c.413N>C | p.Arg138Thr | p.R138T | O60248 | protein_coding | tolerated_low_confidence(0.47) | benign(0.001) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SOX15 | SNV | Missense_Mutation | | c.430G>A | p.Gly144Ser | p.G144S | O60248 | protein_coding | tolerated_low_confidence(0.17) | benign(0.009) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SOX15 | deletion | Frame_Shift_Del | | c.342delN | p.Asp115ThrfsTer116 | p.D115Tfs*116 | O60248 | protein_coding | | | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
SOX15 | deletion | In_Frame_Del | | c.142_144delNNN | p.Lys48del | p.K48del | O60248 | protein_coding | | | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
SOX15 | SNV | Missense_Mutation | novel | c.193N>T | p.Arg65Cys | p.R65C | O60248 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |