GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715594 | Lung | IAC | response to transforming growth factor beta | 60/2061 | 256/18723 | 9.50e-09 | 1.25e-06 | 60 |
GO:00459368 | Lung | IAC | negative regulation of phosphate metabolic process | 87/2061 | 441/18723 | 4.00e-08 | 4.57e-06 | 87 |
GO:00105638 | Lung | IAC | negative regulation of phosphorus metabolic process | 87/2061 | 442/18723 | 4.46e-08 | 4.99e-06 | 87 |
GO:00715604 | Lung | IAC | cellular response to transforming growth factor beta stimulus | 57/2061 | 250/18723 | 6.17e-08 | 6.54e-06 | 57 |
GO:00423268 | Lung | IAC | negative regulation of phosphorylation | 74/2061 | 385/18723 | 1.15e-06 | 6.18e-05 | 74 |
GO:00071794 | Lung | IAC | transforming growth factor beta receptor signaling pathway | 45/2061 | 198/18723 | 1.60e-06 | 7.93e-05 | 45 |
GO:00019338 | Lung | IAC | negative regulation of protein phosphorylation | 66/2061 | 342/18723 | 3.72e-06 | 1.55e-04 | 66 |
GO:00431125 | Lung | IAC | receptor metabolic process | 36/2061 | 166/18723 | 4.93e-05 | 1.13e-03 | 36 |
GO:00071785 | Lung | IAC | transmembrane receptor protein serine/threonine kinase signaling pathway | 60/2061 | 355/18723 | 4.82e-04 | 7.03e-03 | 60 |
GO:19038444 | Lung | IAC | regulation of cellular response to transforming growth factor beta stimulus | 27/2061 | 131/18723 | 9.41e-04 | 1.14e-02 | 27 |
GO:00170153 | Lung | IAC | regulation of transforming growth factor beta receptor signaling pathway | 26/2061 | 128/18723 | 1.45e-03 | 1.55e-02 | 26 |
GO:0030512 | Lung | IAC | negative regulation of transforming growth factor beta receptor signaling pathway | 18/2061 | 81/18723 | 2.68e-03 | 2.46e-02 | 18 |
GO:007155912 | Lung | AIS | response to transforming growth factor beta | 51/1849 | 256/18723 | 8.45e-07 | 6.08e-05 | 51 |
GO:004593613 | Lung | AIS | negative regulation of phosphate metabolic process | 75/1849 | 441/18723 | 1.93e-06 | 1.12e-04 | 75 |
GO:001056313 | Lung | AIS | negative regulation of phosphorus metabolic process | 75/1849 | 442/18723 | 2.11e-06 | 1.20e-04 | 75 |
GO:007156012 | Lung | AIS | cellular response to transforming growth factor beta stimulus | 48/1849 | 250/18723 | 5.13e-06 | 2.47e-04 | 48 |
GO:004232613 | Lung | AIS | negative regulation of phosphorylation | 65/1849 | 385/18723 | 1.17e-05 | 4.69e-04 | 65 |
GO:000717912 | Lung | AIS | transforming growth factor beta receptor signaling pathway | 39/1849 | 198/18723 | 2.08e-05 | 7.12e-04 | 39 |
GO:000193313 | Lung | AIS | negative regulation of protein phosphorylation | 57/1849 | 342/18723 | 5.71e-05 | 1.60e-03 | 57 |
GO:004311212 | Lung | AIS | receptor metabolic process | 32/1849 | 166/18723 | 1.68e-04 | 3.53e-03 | 32 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX25 | SNV | Missense_Mutation | rs754322566 | c.2258N>T | p.Ala753Val | p.A753V | Q9H3E2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SNX25 | SNV | Missense_Mutation | | c.157G>A | p.Val53Met | p.V53M | Q9H3E2 | protein_coding | deleterious(0.03) | benign(0.074) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
SNX25 | SNV | Missense_Mutation | novel | c.2029N>G | p.Arg677Gly | p.R677G | Q9H3E2 | protein_coding | deleterious(0.01) | benign(0.045) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
SNX25 | SNV | Missense_Mutation | | c.2170N>A | p.Asp724Asn | p.D724N | Q9H3E2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX25 | SNV | Missense_Mutation | | c.530N>T | p.Ala177Val | p.A177V | Q9H3E2 | protein_coding | deleterious(0) | possibly_damaging(0.449) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
SNX25 | SNV | Missense_Mutation | | c.574G>A | p.Asp192Asn | p.D192N | Q9H3E2 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
SNX25 | SNV | Missense_Mutation | | c.2043N>T | p.Leu681Phe | p.L681F | Q9H3E2 | protein_coding | deleterious(0.01) | possibly_damaging(0.647) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
SNX25 | insertion | Frame_Shift_Ins | novel | c.2256_2257insTATATATATAGAATCTGTCTAATGACTAACGAAATGGGGTTGT | p.Ala753TyrfsTer39 | p.A753Yfs*39 | Q9H3E2 | protein_coding | | | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SNX25 | SNV | Missense_Mutation | rs779242791 | c.629C>T | p.Ala210Val | p.A210V | Q9H3E2 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNX25 | SNV | Missense_Mutation | | c.1216N>C | p.Glu406Gln | p.E406Q | Q9H3E2 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |