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Gene: SNX24 |
Gene summary for SNX24 |
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Gene information | Species | Human | Gene symbol | SNX24 | Gene ID | 28966 |
Gene name | sorting nexin 24 | |
Gene Alias | PRO1284 | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y343 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28966 | SNX24 | LZE8T | Human | Esophagus | ESCC | 3.71e-02 | 1.08e-01 | 0.067 |
28966 | SNX24 | LZE24T | Human | Esophagus | ESCC | 9.43e-09 | 1.65e-01 | 0.0596 |
28966 | SNX24 | P2T-E | Human | Esophagus | ESCC | 5.79e-06 | 9.68e-02 | 0.1177 |
28966 | SNX24 | P4T-E | Human | Esophagus | ESCC | 3.70e-05 | 1.16e-01 | 0.1323 |
28966 | SNX24 | P5T-E | Human | Esophagus | ESCC | 3.53e-11 | 1.53e-01 | 0.1327 |
28966 | SNX24 | P8T-E | Human | Esophagus | ESCC | 2.93e-06 | 5.61e-02 | 0.0889 |
28966 | SNX24 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.15e-01 | 0.1131 |
28966 | SNX24 | P10T-E | Human | Esophagus | ESCC | 9.01e-07 | 6.25e-02 | 0.116 |
28966 | SNX24 | P12T-E | Human | Esophagus | ESCC | 9.44e-12 | 2.91e-01 | 0.1122 |
28966 | SNX24 | P15T-E | Human | Esophagus | ESCC | 1.10e-02 | 1.16e-01 | 0.1149 |
28966 | SNX24 | P16T-E | Human | Esophagus | ESCC | 1.20e-03 | 4.17e-02 | 0.1153 |
28966 | SNX24 | P20T-E | Human | Esophagus | ESCC | 1.93e-14 | 2.60e-01 | 0.1124 |
28966 | SNX24 | P21T-E | Human | Esophagus | ESCC | 1.45e-06 | 1.55e-01 | 0.1617 |
28966 | SNX24 | P22T-E | Human | Esophagus | ESCC | 2.72e-20 | 3.80e-01 | 0.1236 |
28966 | SNX24 | P23T-E | Human | Esophagus | ESCC | 5.62e-07 | 1.30e-01 | 0.108 |
28966 | SNX24 | P24T-E | Human | Esophagus | ESCC | 7.73e-04 | 1.57e-01 | 0.1287 |
28966 | SNX24 | P26T-E | Human | Esophagus | ESCC | 1.60e-06 | 1.44e-01 | 0.1276 |
28966 | SNX24 | P27T-E | Human | Esophagus | ESCC | 1.05e-09 | 9.03e-02 | 0.1055 |
28966 | SNX24 | P28T-E | Human | Esophagus | ESCC | 2.46e-14 | 2.41e-01 | 0.1149 |
28966 | SNX24 | P30T-E | Human | Esophagus | ESCC | 1.42e-12 | 4.02e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX24 | SNV | Missense_Mutation | novel | c.31N>A | p.Glu11Lys | p.E11K | Q9Y343 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
SNX24 | SNV | Missense_Mutation | rs761488376 | c.43C>A | p.Leu15Met | p.L15M | Q9Y343 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX24 | SNV | Missense_Mutation | rs754151591 | c.121N>A | p.Glu41Lys | p.E41K | Q9Y343 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNX24 | SNV | Missense_Mutation | c.338G>A | p.Ser113Asn | p.S113N | Q9Y343 | protein_coding | tolerated(0.1) | benign(0.143) | TCGA-DC-4749-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNX24 | SNV | Missense_Mutation | rs767703090 | c.491C>A | p.Pro164His | p.P164H | Q9Y343 | protein_coding | deleterious(0) | possibly_damaging(0.455) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SNX24 | SNV | Missense_Mutation | novel | c.254N>A | p.Val85Asp | p.V85D | Q9Y343 | protein_coding | deleterious(0) | possibly_damaging(0.486) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNX24 | SNV | Missense_Mutation | novel | c.92N>T | p.Arg31Ile | p.R31I | Q9Y343 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SNX24 | SNV | Missense_Mutation | c.295T>C | p.Phe99Leu | p.F99L | Q9Y343 | protein_coding | deleterious(0) | benign(0) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
SNX24 | SNV | Missense_Mutation | c.208N>A | p.Val70Ile | p.V70I | Q9Y343 | protein_coding | deleterious(0.04) | probably_damaging(0.956) | TCGA-44-6779-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | taxol | PD | |
SNX24 | SNV | Missense_Mutation | novel | c.191G>A | p.Arg64Lys | p.R64K | Q9Y343 | protein_coding | tolerated(0.26) | probably_damaging(0.946) | TCGA-55-7910-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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