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Gene: SELM |
Gene summary for SELM |
Gene summary. |
Gene information | Species | Human | Gene symbol | SELM | Gene ID | 140606 |
Gene name | selenoprotein M | |
Gene Alias | SELM | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8WWX9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140606 | SELM | GSM4909280 | Human | Breast | Precancer | 5.06e-04 | -5.94e-01 | 0.0305 |
140606 | SELM | GSM4909281 | Human | Breast | IDC | 3.27e-25 | -5.94e-01 | 0.21 |
140606 | SELM | GSM4909282 | Human | Breast | IDC | 2.34e-26 | -5.94e-01 | -0.0288 |
140606 | SELM | GSM4909285 | Human | Breast | IDC | 5.65e-26 | -5.94e-01 | 0.21 |
140606 | SELM | GSM4909286 | Human | Breast | IDC | 1.87e-24 | -5.94e-01 | 0.1081 |
140606 | SELM | GSM4909287 | Human | Breast | IDC | 3.08e-30 | -5.94e-01 | 0.2057 |
140606 | SELM | GSM4909288 | Human | Breast | IDC | 4.63e-08 | -5.94e-01 | 0.0988 |
140606 | SELM | GSM4909289 | Human | Breast | IDC | 6.02e-06 | -5.94e-01 | 0.1064 |
140606 | SELM | GSM4909290 | Human | Breast | IDC | 4.47e-22 | -5.94e-01 | 0.2096 |
140606 | SELM | GSM4909291 | Human | Breast | IDC | 3.78e-18 | -5.94e-01 | 0.1753 |
140606 | SELM | GSM4909292 | Human | Breast | IDC | 6.05e-03 | -5.94e-01 | 0.1236 |
140606 | SELM | GSM4909293 | Human | Breast | IDC | 1.36e-25 | -5.94e-01 | 0.1581 |
140606 | SELM | GSM4909294 | Human | Breast | IDC | 3.27e-25 | -5.94e-01 | 0.2022 |
140606 | SELM | GSM4909295 | Human | Breast | IDC | 1.54e-14 | -5.94e-01 | 0.0898 |
140606 | SELM | GSM4909296 | Human | Breast | IDC | 1.36e-25 | -5.94e-01 | 0.1524 |
140606 | SELM | GSM4909297 | Human | Breast | IDC | 9.66e-27 | -5.94e-01 | 0.1517 |
140606 | SELM | GSM4909298 | Human | Breast | IDC | 1.36e-25 | -5.94e-01 | 0.1551 |
140606 | SELM | GSM4909299 | Human | Breast | IDC | 7.84e-25 | -5.94e-01 | 0.035 |
140606 | SELM | GSM4909300 | Human | Breast | IDC | 5.60e-13 | -5.94e-01 | 0.0334 |
140606 | SELM | GSM4909301 | Human | Breast | IDC | 1.36e-25 | -5.94e-01 | 0.1577 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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