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Gene: S100A8 |
Gene summary for S100A8 |
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Gene information | Species | Human | Gene symbol | S100A8 | Gene ID | 6279 |
Gene name | S100 calcium binding protein A8 | |
Gene Alias | 60B8AG | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P05109 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6279 | S100A8 | GSM4909281 | Human | Breast | IDC | 7.21e-05 | -5.96e-01 | 0.21 |
6279 | S100A8 | GSM4909282 | Human | Breast | IDC | 1.05e-22 | 9.13e-02 | -0.0288 |
6279 | S100A8 | GSM4909285 | Human | Breast | IDC | 1.66e-11 | -7.11e-01 | 0.21 |
6279 | S100A8 | GSM4909286 | Human | Breast | IDC | 3.04e-13 | -7.14e-01 | 0.1081 |
6279 | S100A8 | GSM4909287 | Human | Breast | IDC | 8.51e-03 | -5.33e-01 | 0.2057 |
6279 | S100A8 | GSM4909290 | Human | Breast | IDC | 9.99e-07 | 1.30e-01 | 0.2096 |
6279 | S100A8 | GSM4909291 | Human | Breast | IDC | 2.83e-03 | -6.56e-01 | 0.1753 |
6279 | S100A8 | GSM4909293 | Human | Breast | IDC | 1.35e-11 | -6.97e-01 | 0.1581 |
6279 | S100A8 | GSM4909294 | Human | Breast | IDC | 8.86e-03 | -5.66e-01 | 0.2022 |
6279 | S100A8 | GSM4909297 | Human | Breast | IDC | 4.59e-10 | -7.04e-01 | 0.1517 |
6279 | S100A8 | GSM4909298 | Human | Breast | IDC | 2.44e-15 | -7.14e-01 | 0.1551 |
6279 | S100A8 | GSM4909299 | Human | Breast | IDC | 5.10e-04 | -5.79e-01 | 0.035 |
6279 | S100A8 | GSM4909301 | Human | Breast | IDC | 5.48e-15 | -7.03e-01 | 0.1577 |
6279 | S100A8 | GSM4909302 | Human | Breast | IDC | 6.86e-11 | -6.91e-01 | 0.1545 |
6279 | S100A8 | GSM4909303 | Human | Breast | IDC | 2.85e-03 | -7.14e-01 | 0.0438 |
6279 | S100A8 | GSM4909304 | Human | Breast | IDC | 6.28e-13 | -7.11e-01 | 0.1636 |
6279 | S100A8 | GSM4909305 | Human | Breast | IDC | 9.16e-08 | -7.05e-01 | 0.0436 |
6279 | S100A8 | GSM4909306 | Human | Breast | IDC | 1.66e-06 | -6.72e-01 | 0.1564 |
6279 | S100A8 | GSM4909307 | Human | Breast | IDC | 6.13e-14 | -7.14e-01 | 0.1569 |
6279 | S100A8 | GSM4909308 | Human | Breast | IDC | 4.53e-13 | -7.14e-01 | 0.158 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012429 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway | 41/1080 | 164/18723 | 6.48e-16 | 2.31e-13 | 41 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:20012445 | Breast | Precancer | positive regulation of intrinsic apoptotic signaling pathway | 17/1080 | 58/18723 | 1.59e-08 | 1.12e-06 | 17 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00432808 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/1080 | 129/18723 | 3.13e-07 | 1.50e-05 | 24 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00109509 | Breast | Precancer | positive regulation of endopeptidase activity | 29/1080 | 179/18723 | 4.23e-07 | 1.90e-05 | 29 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00716217 | Breast | Precancer | granulocyte chemotaxis | 23/1080 | 125/18723 | 6.73e-07 | 2.77e-05 | 23 |
GO:20010568 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity | 25/1080 | 148/18723 | 1.19e-06 | 4.60e-05 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465731 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465741 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465751 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465722 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465732 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465726 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa04657113 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465724 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa0465725 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465733 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465743 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
hsa0465753 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A8 | SNV | Missense_Mutation | c.221N>C | p.Leu74Pro | p.L74P | P05109 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
S100A8 | deletion | Frame_Shift_Del | c.256delA | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
S100A8 | deletion | Frame_Shift_Del | c.256delN | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
S100A8 | deletion | Frame_Shift_Del | c.256delN | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
S100A8 | SNV | Missense_Mutation | novel | c.154N>A | p.Asp52Asn | p.D52N | P05109 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S100A8 | SNV | Missense_Mutation | c.207N>T | p.Gln69His | p.Q69H | P05109 | protein_coding | deleterious(0) | benign(0.258) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
S100A8 | SNV | Missense_Mutation | rs780156471 | c.59C>T | p.Ser20Phe | p.S20F | P05109 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD |
S100A8 | SNV | Missense_Mutation | novel | c.245C>T | p.Ala82Val | p.A82V | P05109 | protein_coding | deleterious(0.03) | possibly_damaging(0.494) | TCGA-DI-A1BY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A8 | SNV | Missense_Mutation | novel | c.263N>C | p.Glu88Ala | p.E88A | P05109 | protein_coding | deleterious(0) | benign(0.011) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A8 | insertion | Frame_Shift_Ins | novel | c.256dupA | p.Ser86LysfsTer3 | p.S86Kfs*3 | P05109 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6279 | S100A8 | DRUGGABLE GENOME, KINASE, ENZYME | MTX | METHOTREXATE | 14722212 |
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