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Gene: RPL39P3 |
Gene summary for RPL39P3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | RPL39P3 | Gene ID | 285785 |
| Gene name | ribosomal protein L39 pseudogene 3 | |
| Gene Alias | RPL39_9_712 | |
| Cytomap | 6q13 | |
| Gene Type | pseudo | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 285785 | RPL39P3 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 8.48e-15 | -5.67e-01 | 0.02 |
| 285785 | RPL39P3 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 2.66e-12 | -5.67e-01 | 0.0267 |
| 285785 | RPL39P3 | PTCwithHT_1 | Human | Thyroid | HT | 3.75e-04 | -5.67e-01 | 0.0238 |
| 285785 | RPL39P3 | PTCwithHT_6 | Human | Thyroid | HT | 6.45e-07 | -5.64e-01 | 0.02 |
| 285785 | RPL39P3 | PTCwithHT_8 | Human | Thyroid | HT | 7.18e-11 | -5.59e-01 | 0.0351 |
| 285785 | RPL39P3 | PTCwithoutHT_2 | Human | Thyroid | PTC | 8.48e-15 | -5.67e-01 | 0.0419 |
| 285785 | RPL39P3 | PTCwithoutHT_7 | Human | Thyroid | PTC | 3.75e-04 | -5.67e-01 | 0.0381 |
| 285785 | RPL39P3 | male-WTA | Human | Thyroid | PTC | 4.65e-45 | -2.04e-01 | 0.1037 |
| 285785 | RPL39P3 | nodule-WTA | Human | Thyroid | goiters | 1.10e-03 | -4.47e-01 | 0.0534 |
| 285785 | RPL39P3 | PTC01 | Human | Thyroid | PTC | 2.12e-13 | -5.67e-01 | 0.1899 |
| 285785 | RPL39P3 | PTC03 | Human | Thyroid | PTC | 5.31e-04 | -5.67e-01 | 0.1784 |
| 285785 | RPL39P3 | PTC04 | Human | Thyroid | PTC | 2.12e-13 | -5.67e-01 | 0.1927 |
| 285785 | RPL39P3 | PTC05 | Human | Thyroid | PTC | 3.15e-04 | -5.67e-01 | 0.2065 |
| 285785 | RPL39P3 | PTC06 | Human | Thyroid | PTC | 3.52e-10 | -5.67e-01 | 0.2057 |
| 285785 | RPL39P3 | PTC07 | Human | Thyroid | PTC | 5.88e-09 | -5.67e-01 | 0.2044 |
| 285785 | RPL39P3 | ATC08 | Human | Thyroid | ATC | 1.07e-03 | -5.67e-01 | 0.0541 |
| 285785 | RPL39P3 | ATC09 | Human | Thyroid | ATC | 1.88e-04 | -5.67e-01 | 0.2871 |
| 285785 | RPL39P3 | ATC12 | Human | Thyroid | ATC | 1.90e-14 | -5.67e-01 | 0.34 |
| 285785 | RPL39P3 | ATC13 | Human | Thyroid | ATC | 5.88e-09 | -5.67e-01 | 0.34 |
| 285785 | RPL39P3 | ATC1 | Human | Thyroid | ATC | 2.19e-03 | -5.67e-01 | 0.2878 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Thyroid | PTC |  |
| Thyroid | goiters |  |
| Thyroid | ATC |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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