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Gene: RPF2 |
Gene summary for RPF2 |
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Gene information | Species | Human | Gene symbol | RPF2 | Gene ID | 84154 |
Gene name | ribosome production factor 2 homolog | |
Gene Alias | BXDC1 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000027 | UniProtAcc | Q9H7B2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84154 | RPF2 | LZE4T | Human | Esophagus | ESCC | 3.81e-12 | 5.53e-02 | 0.0811 |
84154 | RPF2 | LZE8T | Human | Esophagus | ESCC | 9.16e-03 | -1.47e-01 | 0.067 |
84154 | RPF2 | LZE22D1 | Human | Esophagus | HGIN | 3.06e-05 | -9.31e-02 | 0.0595 |
84154 | RPF2 | LZE24T | Human | Esophagus | ESCC | 1.59e-06 | 2.42e-01 | 0.0596 |
84154 | RPF2 | LZE6T | Human | Esophagus | ESCC | 8.02e-07 | 8.42e-03 | 0.0845 |
84154 | RPF2 | P1T-E | Human | Esophagus | ESCC | 2.90e-05 | -3.50e-03 | 0.0875 |
84154 | RPF2 | P2T-E | Human | Esophagus | ESCC | 6.01e-19 | 2.53e-01 | 0.1177 |
84154 | RPF2 | P4T-E | Human | Esophagus | ESCC | 1.45e-16 | 5.13e-01 | 0.1323 |
84154 | RPF2 | P5T-E | Human | Esophagus | ESCC | 1.13e-22 | 5.89e-01 | 0.1327 |
84154 | RPF2 | P8T-E | Human | Esophagus | ESCC | 7.91e-16 | 1.73e-02 | 0.0889 |
84154 | RPF2 | P9T-E | Human | Esophagus | ESCC | 2.55e-13 | 2.00e-01 | 0.1131 |
84154 | RPF2 | P10T-E | Human | Esophagus | ESCC | 6.95e-17 | 2.81e-01 | 0.116 |
84154 | RPF2 | P11T-E | Human | Esophagus | ESCC | 9.17e-10 | 8.83e-02 | 0.1426 |
84154 | RPF2 | P12T-E | Human | Esophagus | ESCC | 1.53e-22 | 3.96e-01 | 0.1122 |
84154 | RPF2 | P15T-E | Human | Esophagus | ESCC | 4.34e-16 | 5.05e-01 | 0.1149 |
84154 | RPF2 | P16T-E | Human | Esophagus | ESCC | 5.86e-23 | 5.62e-01 | 0.1153 |
84154 | RPF2 | P19T-E | Human | Esophagus | ESCC | 2.43e-02 | 4.97e-01 | 0.1662 |
84154 | RPF2 | P20T-E | Human | Esophagus | ESCC | 1.17e-15 | 1.74e-01 | 0.1124 |
84154 | RPF2 | P21T-E | Human | Esophagus | ESCC | 5.21e-20 | 8.39e-01 | 0.1617 |
84154 | RPF2 | P22T-E | Human | Esophagus | ESCC | 1.72e-19 | -5.18e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002261827 | Esophagus | HGIN | ribonucleoprotein complex assembly | 82/2587 | 220/18723 | 2.07e-18 | 7.36e-16 | 82 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:003450417 | Esophagus | HGIN | protein localization to nucleus | 84/2587 | 290/18723 | 1.06e-11 | 1.24e-09 | 84 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:004225527 | Esophagus | HGIN | ribosome assembly | 28/2587 | 61/18723 | 1.36e-09 | 1.07e-07 | 28 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:007233127 | Esophagus | HGIN | signal transduction by p53 class mediator | 49/2587 | 163/18723 | 5.71e-08 | 3.06e-06 | 49 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:000002726 | Esophagus | HGIN | ribosomal large subunit assembly | 13/2587 | 27/18723 | 1.95e-05 | 5.24e-04 | 13 |
GO:190179627 | Esophagus | HGIN | regulation of signal transduction by p53 class mediator | 26/2587 | 93/18723 | 2.60e-04 | 4.55e-03 | 26 |
GO:00004707 | Esophagus | HGIN | maturation of LSU-rRNA | 10/2587 | 28/18723 | 3.04e-03 | 2.88e-02 | 10 |
GO:19025702 | Esophagus | HGIN | protein localization to nucleolus | 7/2587 | 16/18723 | 3.47e-03 | 3.22e-02 | 7 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPF2 | insertion | In_Frame_Ins | novel | c.13_14insGGCGCGATCTCCGCTCACTGCAACCTCCGCCTCCCGGGTTCA | p.Asp5delinsGlyArgAspLeuArgSerLeuGlnProProProProGlyPheAsn | p.D5delinsGRDLRSLQPPPPGFN | Q9H7B2 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
RPF2 | SNV | Missense_Mutation | novel | c.386A>G | p.Asp129Gly | p.D129G | Q9H7B2 | protein_coding | deleterious(0.01) | benign(0.257) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPF2 | SNV | Missense_Mutation | novel | c.727C>T | p.Pro243Ser | p.P243S | Q9H7B2 | protein_coding | deleterious(0.01) | possibly_damaging(0.741) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPF2 | SNV | Missense_Mutation | rs575146968 | c.736N>G | p.Leu246Val | p.L246V | Q9H7B2 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
RPF2 | SNV | Missense_Mutation | novel | c.112G>T | p.Gly38Trp | p.G38W | Q9H7B2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPF2 | SNV | Missense_Mutation | c.587N>A | p.Arg196Gln | p.R196Q | Q9H7B2 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPF2 | SNV | Missense_Mutation | c.756A>C | p.Lys252Asn | p.K252N | Q9H7B2 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RPF2 | SNV | Missense_Mutation | c.677G>T | p.Arg226Met | p.R226M | Q9H7B2 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPF2 | SNV | Missense_Mutation | c.205N>G | p.Thr69Ala | p.T69A | Q9H7B2 | protein_coding | tolerated(0.51) | benign(0.026) | TCGA-AF-2687-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD | |
RPF2 | SNV | Missense_Mutation | c.527N>T | p.Arg176Leu | p.R176L | Q9H7B2 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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