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Gene: PTP4A1 |
Gene summary for PTP4A1 |
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Gene information | Species | Human | Gene symbol | PTP4A1 | Gene ID | 7803 |
Gene name | protein tyrosine phosphatase 4A1 | |
Gene Alias | HH72 | |
Cytomap | 6q12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R8J2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7803 | PTP4A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.69e-13 | 7.63e-01 | -0.1088 |
7803 | PTP4A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.74e-10 | 5.12e-01 | -0.1954 |
7803 | PTP4A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.88e-03 | 4.54e-01 | -0.1526 |
7803 | PTP4A1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.24e-03 | 5.22e-01 | -0.2061 |
7803 | PTP4A1 | A015-C-203 | Human | Colorectum | FAP | 2.39e-05 | -1.72e-01 | -0.1294 |
7803 | PTP4A1 | A001-C-119 | Human | Colorectum | FAP | 2.29e-02 | -2.46e-01 | -0.1557 |
7803 | PTP4A1 | A001-C-108 | Human | Colorectum | FAP | 1.97e-04 | -1.59e-01 | -0.0272 |
7803 | PTP4A1 | A002-C-205 | Human | Colorectum | FAP | 7.44e-05 | -2.27e-01 | -0.1236 |
7803 | PTP4A1 | A015-C-106 | Human | Colorectum | FAP | 2.65e-04 | -1.74e-01 | -0.0511 |
7803 | PTP4A1 | A015-C-104 | Human | Colorectum | FAP | 5.99e-08 | -1.95e-01 | -0.1899 |
7803 | PTP4A1 | A001-C-203 | Human | Colorectum | FAP | 1.37e-04 | -1.69e-01 | -0.0481 |
7803 | PTP4A1 | A002-C-116 | Human | Colorectum | FAP | 1.86e-07 | -1.86e-01 | -0.0452 |
7803 | PTP4A1 | A014-C-008 | Human | Colorectum | FAP | 1.78e-02 | -2.50e-01 | -0.191 |
7803 | PTP4A1 | F034 | Human | Colorectum | FAP | 7.22e-04 | -1.85e-01 | -0.0665 |
7803 | PTP4A1 | LZE4T | Human | Esophagus | ESCC | 8.33e-19 | -9.89e-01 | 0.0811 |
7803 | PTP4A1 | LZE5T | Human | Esophagus | ESCC | 2.50e-05 | -9.89e-01 | 0.0514 |
7803 | PTP4A1 | LZE7T | Human | Esophagus | ESCC | 5.98e-09 | -9.48e-01 | 0.0667 |
7803 | PTP4A1 | LZE8T | Human | Esophagus | ESCC | 4.31e-17 | -9.89e-01 | 0.067 |
7803 | PTP4A1 | LZE20T | Human | Esophagus | ESCC | 2.21e-17 | -9.89e-01 | 0.0662 |
7803 | PTP4A1 | LZE21D1 | Human | Esophagus | HGIN | 5.17e-04 | -9.89e-01 | 0.0632 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
GO:0035335 | Colorectum | FAP | peptidyl-tyrosine dephosphorylation | 23/2622 | 97/18723 | 6.95e-03 | 4.26e-02 | 23 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:000647011 | Liver | Cirrhotic | protein dephosphorylation | 96/4634 | 281/18723 | 2.32e-04 | 2.11e-03 | 96 |
GO:001631111 | Liver | Cirrhotic | dephosphorylation | 130/4634 | 417/18723 | 1.58e-03 | 1.03e-02 | 130 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:00064707 | Lung | IAC | protein dephosphorylation | 60/2061 | 281/18723 | 3.24e-07 | 2.48e-05 | 60 |
GO:00163116 | Lung | IAC | dephosphorylation | 75/2061 | 417/18723 | 1.21e-05 | 3.64e-04 | 75 |
GO:00353353 | Lung | IAC | peptidyl-tyrosine dephosphorylation | 23/2061 | 97/18723 | 2.79e-04 | 4.56e-03 | 23 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:000647016 | Oral cavity | LP | protein dephosphorylation | 89/4623 | 281/18723 | 4.60e-03 | 2.93e-02 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTP4A1 | SNV | Missense_Mutation | rs529722832 | c.83C>T | p.Ala28Val | p.A28V | Q93096 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTP4A1 | SNV | Missense_Mutation | novel | c.344T>A | p.Val115Asp | p.V115D | Q93096 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTP4A1 | SNV | Missense_Mutation | rs529722832 | c.83N>T | p.Ala28Val | p.A28V | Q93096 | protein_coding | tolerated(0.15) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTP4A1 | SNV | Missense_Mutation | novel | c.379N>A | p.Glu127Lys | p.E127K | Q93096 | protein_coding | tolerated(0.09) | benign(0.213) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTP4A1 | SNV | Missense_Mutation | c.316N>A | p.Ala106Thr | p.A106T | Q93096 | protein_coding | deleterious(0.05) | benign(0.119) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
PTP4A1 | SNV | Missense_Mutation | novel | c.432N>T | p.Lys144Asn | p.K144N | Q93096 | protein_coding | deleterious(0.02) | probably_damaging(0.92) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PTP4A1 | SNV | Missense_Mutation | c.17G>A | p.Arg6His | p.R6H | Q93096 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
PTP4A1 | SNV | Missense_Mutation | novel | c.8N>A | p.Arg3Gln | p.R3Q | Q93096 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PTP4A1 | SNV | Missense_Mutation | novel | c.457N>T | p.Arg153Cys | p.R153C | Q93096 | protein_coding | tolerated(0.1) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTP4A1 | SNV | Missense_Mutation | rs777437055 | c.116N>G | p.Lys39Arg | p.K39R | Q93096 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7803 | PTP4A1 | DRUGGABLE GENOME, PROTEIN PHOSPHATASE | HALOFUGINONE | HALOFUGINONE | 16508789 |
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