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Gene: PPIL6 |
Gene summary for PPIL6 |
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Gene information | Species | Human | Gene symbol | PPIL6 | Gene ID | 285755 |
Gene name | peptidylprolyl isomerase like 6 | |
Gene Alias | PPIase | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | Q8IXY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285755 | PPIL6 | HCC1 | Human | Liver | HCC | 3.74e-07 | 9.01e-01 | 0.5336 |
285755 | PPIL6 | HCC2 | Human | Liver | HCC | 2.89e-08 | 2.38e+00 | 0.5341 |
285755 | PPIL6 | HCC5 | Human | Liver | HCC | 6.76e-05 | 6.69e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:001820811 | Liver | HCC | peptidyl-proline modification | 42/7958 | 58/18723 | 3.73e-06 | 4.85e-05 | 42 |
GO:00004131 | Liver | HCC | protein peptidyl-prolyl isomerization | 31/7958 | 42/18723 | 3.83e-05 | 3.80e-04 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPIL6 | SNV | Missense_Mutation | novel | c.144N>C | p.Lys48Asn | p.K48N | Q8IXY8 | protein_coding | deleterious(0.02) | possibly_damaging(0.741) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPIL6 | deletion | Frame_Shift_Del | novel | c.1009delN | p.Ala337LeufsTer17 | p.A337Lfs*17 | Q8IXY8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PPIL6 | SNV | Missense_Mutation | rs763721663 | c.376N>A | p.Ala126Thr | p.A126T | Q8IXY8 | protein_coding | tolerated(0.07) | possibly_damaging(0.511) | TCGA-HG-A2PA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Taxol | PD |
PPIL6 | SNV | Missense_Mutation | novel | c.1003C>G | p.Pro335Ala | p.P335A | Q8IXY8 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
PPIL6 | SNV | Missense_Mutation | rs764934185 | c.275N>A | p.Ser92Tyr | p.S92Y | Q8IXY8 | protein_coding | deleterious(0) | benign(0.242) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPIL6 | SNV | Missense_Mutation | novel | c.356N>C | p.Lys119Thr | p.K119T | Q8IXY8 | protein_coding | deleterious(0.02) | benign(0.201) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIL6 | SNV | Missense_Mutation | novel | c.680N>T | p.Thr227Ile | p.T227I | Q8IXY8 | protein_coding | tolerated(0.06) | benign(0.139) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPIL6 | SNV | Missense_Mutation | rs567517121 | c.890T>G | p.Phe297Cys | p.F297C | Q8IXY8 | protein_coding | tolerated(0.08) | benign(0.012) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
PPIL6 | SNV | Missense_Mutation | c.521N>G | p.Phe174Cys | p.F174C | Q8IXY8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPIL6 | SNV | Missense_Mutation | novel | c.487T>C | p.Tyr163His | p.Y163H | Q8IXY8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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