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Gene: PLEKHM3 |
Gene summary for PLEKHM3 |
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Gene information | Species | Human | Gene symbol | PLEKHM3 | Gene ID | 389072 |
Gene name | pleckstrin homology domain containing M3 | |
Gene Alias | DAPR | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6ZWE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389072 | PLEKHM3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.91e-02 | -2.61e-01 | 0.0155 |
389072 | PLEKHM3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.24e-02 | -2.67e-01 | 0.096 |
389072 | PLEKHM3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.42e-37 | 1.45e+00 | 0.3005 |
389072 | PLEKHM3 | A001-C-207 | Human | Colorectum | FAP | 1.51e-03 | -3.13e-01 | 0.1278 |
389072 | PLEKHM3 | A015-C-203 | Human | Colorectum | FAP | 3.74e-15 | -3.69e-01 | -0.1294 |
389072 | PLEKHM3 | A015-C-204 | Human | Colorectum | FAP | 2.80e-05 | -3.00e-01 | -0.0228 |
389072 | PLEKHM3 | A002-C-201 | Human | Colorectum | FAP | 8.05e-11 | -3.31e-01 | 0.0324 |
389072 | PLEKHM3 | A002-C-203 | Human | Colorectum | FAP | 2.10e-04 | -2.29e-01 | 0.2786 |
389072 | PLEKHM3 | A001-C-119 | Human | Colorectum | FAP | 5.89e-03 | -2.70e-01 | -0.1557 |
389072 | PLEKHM3 | A001-C-108 | Human | Colorectum | FAP | 2.08e-09 | -2.91e-01 | -0.0272 |
389072 | PLEKHM3 | A002-C-205 | Human | Colorectum | FAP | 8.94e-12 | -3.34e-01 | -0.1236 |
389072 | PLEKHM3 | A001-C-104 | Human | Colorectum | FAP | 3.55e-03 | -3.11e-01 | 0.0184 |
389072 | PLEKHM3 | A015-C-005 | Human | Colorectum | FAP | 4.16e-04 | -2.83e-01 | -0.0336 |
389072 | PLEKHM3 | A015-C-006 | Human | Colorectum | FAP | 5.39e-10 | -3.96e-01 | -0.0994 |
389072 | PLEKHM3 | A015-C-106 | Human | Colorectum | FAP | 1.67e-07 | -2.95e-01 | -0.0511 |
389072 | PLEKHM3 | A002-C-114 | Human | Colorectum | FAP | 5.39e-14 | -4.26e-01 | -0.1561 |
389072 | PLEKHM3 | A015-C-104 | Human | Colorectum | FAP | 1.34e-15 | -3.35e-01 | -0.1899 |
389072 | PLEKHM3 | A001-C-014 | Human | Colorectum | FAP | 5.72e-07 | -3.09e-01 | 0.0135 |
389072 | PLEKHM3 | A002-C-016 | Human | Colorectum | FAP | 1.08e-10 | -3.49e-01 | 0.0521 |
389072 | PLEKHM3 | A015-C-002 | Human | Colorectum | FAP | 4.79e-12 | -4.78e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHM3 | SNV | Missense_Mutation | rs537158571 | c.522G>C | p.Gln174His | p.Q174H | Q6ZWE6 | protein_coding | tolerated(0.18) | possibly_damaging(0.648) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PLEKHM3 | SNV | Missense_Mutation | c.570G>T | p.Leu190Phe | p.L190F | Q6ZWE6 | protein_coding | tolerated(0.7) | benign(0.058) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD | |
PLEKHM3 | insertion | In_Frame_Ins | novel | c.1996_1997insCTACACGGTATGTGTGTGCACTGGCCT | p.Lys665_Phe666insSerThrArgTyrValCysAlaLeuAla | p.K665_F666insSTRYVCALA | Q6ZWE6 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PLEKHM3 | insertion | Frame_Shift_Ins | novel | c.346_347insTAAAATTTAAAAACATACCAGTATTT | p.Thr116IlefsTer27 | p.T116Ifs*27 | Q6ZWE6 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
PLEKHM3 | SNV | Missense_Mutation | novel | c.602G>T | p.Gly201Val | p.G201V | Q6ZWE6 | protein_coding | tolerated(0.08) | possibly_damaging(0.685) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLEKHM3 | SNV | Missense_Mutation | novel | c.1528N>G | p.Gln510Glu | p.Q510E | Q6ZWE6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHM3 | SNV | Missense_Mutation | rs750548446 | c.377N>A | p.Arg126Gln | p.R126Q | Q6ZWE6 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-EX-A1H5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLEKHM3 | SNV | Missense_Mutation | rs375834227 | c.2183G>A | p.Arg728Gln | p.R728Q | Q6ZWE6 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLEKHM3 | SNV | Missense_Mutation | c.28N>C | p.Ser10Arg | p.S10R | Q6ZWE6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLEKHM3 | SNV | Missense_Mutation | c.1979N>C | p.Leu660Ser | p.L660S | Q6ZWE6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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