![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PDP2 |
Gene summary for PDP2 |
![]() |
Gene information | Species | Human | Gene symbol | PDP2 | Gene ID | 57546 |
Gene name | pyruvate dehyrogenase phosphatase catalytic subunit 2 | |
Gene Alias | PDPC 2 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9P2J9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57546 | PDP2 | HCC1_Meng | Human | Liver | HCC | 9.99e-11 | 1.12e-02 | 0.0246 |
57546 | PDP2 | HCC1 | Human | Liver | HCC | 1.52e-17 | 1.90e+00 | 0.5336 |
57546 | PDP2 | HCC2 | Human | Liver | HCC | 4.28e-40 | 3.39e+00 | 0.5341 |
57546 | PDP2 | HCC5 | Human | Liver | HCC | 1.83e-33 | 2.52e+00 | 0.4932 |
57546 | PDP2 | S028 | Human | Liver | HCC | 1.69e-11 | 3.53e-01 | 0.2503 |
57546 | PDP2 | S029 | Human | Liver | HCC | 3.16e-02 | 1.84e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDP2 | SNV | Missense_Mutation | rs779266449 | c.956G>A | p.Arg319Gln | p.R319Q | Q9P2J9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
PDP2 | insertion | Nonsense_Mutation | novel | c.1351_1352insATGGGACTAAGCATTGAAGAAGCAT | p.Met451AsnfsTer6 | p.M451Nfs*6 | Q9P2J9 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PDP2 | insertion | Frame_Shift_Ins | novel | c.1502_1503insGTTCACACCCCCACACTACTACACTCCACCCTACCTGACTGCTGAGC | p.Asp501GlufsTer55 | p.D501Efs*55 | Q9P2J9 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
PDP2 | insertion | Nonsense_Mutation | novel | c.152_153insAGTTTAGTGTATTTTAAATAGTTTATTCTAAGTCATTT | p.Ser51ArgfsTer3 | p.S51Rfs*3 | Q9P2J9 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PDP2 | insertion | In_Frame_Ins | novel | c.1218_1219insGAGGCGGAGCTTGCAGTGAGCAGAGATCACACCACTGCA | p.Phe406_Leu407insGluAlaGluLeuAlaValSerArgAspHisThrThrAla | p.F406_L407insEAELAVSRDHTTA | Q9P2J9 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
PDP2 | deletion | Frame_Shift_Del | novel | c.974delC | p.Pro325LeufsTer29 | p.P325Lfs*29 | Q9P2J9 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PDP2 | SNV | Missense_Mutation | c.980N>T | p.Ser327Leu | p.S327L | Q9P2J9 | protein_coding | deleterious(0.03) | possibly_damaging(0.555) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDP2 | SNV | Missense_Mutation | novel | c.1241N>C | p.Leu414Pro | p.L414P | Q9P2J9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PDP2 | SNV | Missense_Mutation | c.1038N>C | p.Arg346Ser | p.R346S | Q9P2J9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDP2 | SNV | Missense_Mutation | c.815N>T | p.Ala272Val | p.A272V | Q9P2J9 | protein_coding | tolerated(0.08) | possibly_damaging(0.859) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |