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Gene: NPDC1 |
Gene summary for NPDC1 |
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Gene information | Species | Human | Gene symbol | NPDC1 | Gene ID | 56654 |
Gene name | neural proliferation, differentiation and control 1 | |
Gene Alias | CAB | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NQX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56654 | NPDC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.70e-12 | 2.59e-01 | 0.0155 |
56654 | NPDC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.58e-13 | 4.76e-01 | -0.1808 |
56654 | NPDC1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.97e-03 | 3.20e-01 | 0.0216 |
56654 | NPDC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-23 | 5.83e-01 | -0.0811 |
56654 | NPDC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.19e-22 | 5.75e-01 | -0.1088 |
56654 | NPDC1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.97e-08 | 6.45e-01 | -0.2602 |
56654 | NPDC1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.03e-10 | 9.07e-01 | -0.2196 |
56654 | NPDC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.24e-15 | 6.40e-01 | -0.1207 |
56654 | NPDC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.93e-23 | 5.53e-01 | -0.1464 |
56654 | NPDC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.69e-11 | 4.06e-01 | -0.1001 |
56654 | NPDC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.27e-25 | 7.09e-01 | -0.059 |
56654 | NPDC1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.17e-02 | 3.41e-01 | -0.1706 |
56654 | NPDC1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.90e-08 | 4.52e-01 | -0.0842 |
56654 | NPDC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.88e-22 | 4.89e-01 | 0.096 |
56654 | NPDC1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.18e-05 | 5.70e-01 | 0.0451 |
56654 | NPDC1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.80e-04 | 3.31e-01 | 0.0528 |
56654 | NPDC1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.32e-05 | 3.72e-01 | -0.0177 |
56654 | NPDC1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.89e-31 | 7.93e-01 | 0.0338 |
56654 | NPDC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.75e-30 | 6.82e-01 | 0.0674 |
56654 | NPDC1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.87e-09 | 3.61e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPDC1 | SNV | Missense_Mutation | c.334N>A | p.Gly112Arg | p.G112R | Q9NQX5 | protein_coding | tolerated(0.48) | benign(0.213) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NPDC1 | SNV | Missense_Mutation | c.265N>A | p.Gly89Ser | p.G89S | Q9NQX5 | protein_coding | tolerated(0.82) | benign(0.054) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
NPDC1 | SNV | Missense_Mutation | c.832G>C | p.Glu278Gln | p.E278Q | Q9NQX5 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
NPDC1 | insertion | Frame_Shift_Ins | novel | c.350_351insAAGA | p.Leu118ArgfsTer96 | p.L118Rfs*96 | Q9NQX5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
NPDC1 | SNV | Missense_Mutation | rs778983633 | c.407G>A | p.Arg136Gln | p.R136Q | Q9NQX5 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs564238459 | c.406C>T | p.Arg136Trp | p.R136W | Q9NQX5 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
NPDC1 | SNV | Missense_Mutation | novel | c.141N>A | p.Asp47Glu | p.D47E | Q9NQX5 | protein_coding | tolerated(0.1) | benign(0.207) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs751469138 | c.445N>A | p.Gly149Arg | p.G149R | Q9NQX5 | protein_coding | deleterious(0.05) | probably_damaging(0.929) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NPDC1 | SNV | Missense_Mutation | rs780477037 | c.928G>A | p.Ala310Thr | p.A310T | Q9NQX5 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | novel | c.742N>G | p.Met248Val | p.M248V | Q9NQX5 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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