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Gene: NBPF14 |
Gene summary for NBPF14 |
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Gene information | Species | Human | Gene symbol | NBPF14 | Gene ID | 25832 |
Gene name | NBPF member 14 | |
Gene Alias | DJ328E19.C1.1 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WZJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25832 | NBPF14 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.72e-15 | 1.10e+00 | -0.1954 |
25832 | NBPF14 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.60e-03 | 5.81e-01 | -0.1526 |
25832 | NBPF14 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.54e-04 | 4.60e-01 | -0.1001 |
25832 | NBPF14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.01e-02 | 3.58e-01 | -0.059 |
25832 | NBPF14 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.22e-03 | 2.45e-01 | 0.0674 |
25832 | NBPF14 | A015-C-203 | Human | Colorectum | FAP | 6.95e-04 | 1.41e-01 | -0.1294 |
25832 | NBPF14 | A015-C-104 | Human | Colorectum | FAP | 2.00e-03 | 5.02e-02 | -0.1899 |
25832 | NBPF14 | A002-C-116 | Human | Colorectum | FAP | 7.89e-06 | -9.20e-02 | -0.0452 |
25832 | NBPF14 | CRC-1-8810 | Human | Colorectum | CRC | 2.09e-02 | -1.58e-01 | 0.6257 |
25832 | NBPF14 | CRC-3-11773 | Human | Colorectum | CRC | 3.35e-02 | -1.76e-01 | 0.2564 |
25832 | NBPF14 | LZE4T | Human | Esophagus | ESCC | 2.53e-02 | 9.40e-02 | 0.0811 |
25832 | NBPF14 | LZE5T | Human | Esophagus | ESCC | 3.95e-02 | 3.57e-01 | 0.0514 |
25832 | NBPF14 | LZE20T | Human | Esophagus | ESCC | 1.27e-03 | 7.27e-02 | 0.0662 |
25832 | NBPF14 | LZE24T | Human | Esophagus | ESCC | 4.13e-04 | 1.54e-01 | 0.0596 |
25832 | NBPF14 | P1T-E | Human | Esophagus | ESCC | 1.81e-28 | 1.37e+00 | 0.0875 |
25832 | NBPF14 | P2T-E | Human | Esophagus | ESCC | 1.26e-16 | 3.04e-01 | 0.1177 |
25832 | NBPF14 | P5T-E | Human | Esophagus | ESCC | 3.26e-23 | 4.52e-01 | 0.1327 |
25832 | NBPF14 | P8T-E | Human | Esophagus | ESCC | 5.04e-11 | 1.49e-01 | 0.0889 |
25832 | NBPF14 | P9T-E | Human | Esophagus | ESCC | 2.45e-11 | 1.89e-01 | 0.1131 |
25832 | NBPF14 | P10T-E | Human | Esophagus | ESCC | 2.05e-18 | 3.42e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF14 | SNV | Missense_Mutation | novel | c.4984G>A | p.Asp1662Asn | p.D1662N | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.3493N>T | p.Ile1165Phe | p.I1165F | protein_coding | tolerated(0.07) | benign(0.249) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.5N>C | p.Val2Ala | p.V2A | protein_coding | tolerated(0.06) | benign(0.285) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.8605G>A | p.Asp2869Asn | p.D2869N | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
NBPF14 | SNV | Missense_Mutation | novel | c.1081N>A | p.Glu361Lys | p.E361K | protein_coding | deleterious(0.02) | possibly_damaging(0.486) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1827N>T | p.Lys609Asn | p.K609N | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-EW-A1OX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.193G>C | p.Asp65His | p.D65H | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | insertion | Frame_Shift_Ins | novel | c.8645_8646insT | p.Arg2882SerfsTer39 | p.R2882Sfs*39 | protein_coding | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
NBPF14 | SNV | Missense_Mutation | novel | c.251N>G | p.Glu84Gly | p.E84G | protein_coding | deleterious(0) | possibly_damaging(0.479) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1044N>G | p.Phe348Leu | p.F348L | protein_coding | tolerated(0.22) | benign(0.294) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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