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Gene: NBPF10 |
Gene summary for NBPF10 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NBPF10 | Gene ID | 100132406 |
Gene name | NBPF member 10 | |
Gene Alias | AB6 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A075B762 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100132406 | NBPF10 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.42e-09 | 4.57e-01 | -0.1954 |
100132406 | NBPF10 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.37e-03 | 3.35e-01 | -0.1526 |
100132406 | NBPF10 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.29e-02 | 1.40e-01 | -0.1001 |
100132406 | NBPF10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.17e-02 | 3.02e-01 | -0.0179 |
100132406 | NBPF10 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.07e-02 | 2.13e-01 | 0.096 |
100132406 | NBPF10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.06e-02 | 3.22e-01 | 0.0171 |
100132406 | NBPF10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.06e-02 | 1.40e-01 | 0.0674 |
100132406 | NBPF10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.49e-11 | 2.40e-01 | 0.294 |
100132406 | NBPF10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.33e-05 | 1.81e-01 | 0.3859 |
100132406 | NBPF10 | HCC1 | Human | Liver | HCC | 4.93e-03 | 1.63e+00 | 0.5336 |
100132406 | NBPF10 | HCC2 | Human | Liver | HCC | 8.93e-27 | 2.68e+00 | 0.5341 |
100132406 | NBPF10 | HCC5 | Human | Liver | HCC | 8.28e-03 | 7.69e-01 | 0.4932 |
100132406 | NBPF10 | Pt13.b | Human | Liver | HCC | 2.55e-10 | 2.05e-01 | 0.0251 |
100132406 | NBPF10 | Pt14.a | Human | Liver | HCC | 4.85e-03 | 2.25e-01 | 0.0169 |
100132406 | NBPF10 | S027 | Human | Liver | HCC | 3.07e-14 | 1.15e+00 | 0.2446 |
100132406 | NBPF10 | S028 | Human | Liver | HCC | 3.15e-31 | 1.15e+00 | 0.2503 |
100132406 | NBPF10 | S029 | Human | Liver | HCC | 3.46e-20 | 7.51e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF10 | SNV | Missense_Mutation | novel | c.2530G>A | p.Glu844Lys | p.E844K | protein_coding | tolerated(1) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.2732N>A | p.Arg911His | p.R911H | protein_coding | tolerated(1) | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
NBPF10 | SNV | Missense_Mutation | novel | c.10895C>G | p.Pro3632Arg | p.P3632R | protein_coding | deleterious(0.01) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | ||
NBPF10 | SNV | Missense_Mutation | rs370974831 | c.268N>C | p.Glu90Gln | p.E90Q | protein_coding | tolerated(0.18) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.2530N>A | p.Glu844Lys | p.E844K | protein_coding | tolerated(1) | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.1942N>C | p.Glu648Gln | p.E648Q | protein_coding | deleterious(0.05) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.1942G>C | p.Glu648Gln | p.E648Q | protein_coding | deleterious(0.05) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.1927N>G | p.Pro643Ala | p.P643A | protein_coding | tolerated(0.12) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.11114G>A | p.Gly3705Glu | p.G3705E | protein_coding | tolerated(1) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
NBPF10 | SNV | Missense_Mutation | novel | c.1003A>G | p.Lys335Glu | p.K335E | protein_coding | tolerated(0.45) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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