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Gene: N4BP2L1 |
Gene summary for N4BP2L1 |
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Gene information | Species | Human | Gene symbol | N4BP2L1 | Gene ID | 90634 |
Gene name | NEDD4 binding protein 2 like 1 | |
Gene Alias | CG018 | |
Cytomap | 13q13.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A024RDV1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90634 | N4BP2L1 | LZE4T | Human | Esophagus | ESCC | 3.35e-02 | 1.11e-01 | 0.0811 |
90634 | N4BP2L1 | LZE7T | Human | Esophagus | ESCC | 3.32e-02 | 9.65e-02 | 0.0667 |
90634 | N4BP2L1 | LZE22T | Human | Esophagus | ESCC | 1.52e-02 | 1.61e-01 | 0.068 |
90634 | N4BP2L1 | LZE24T | Human | Esophagus | ESCC | 9.82e-07 | 1.44e-01 | 0.0596 |
90634 | N4BP2L1 | P2T-E | Human | Esophagus | ESCC | 7.31e-17 | 2.23e-01 | 0.1177 |
90634 | N4BP2L1 | P4T-E | Human | Esophagus | ESCC | 9.04e-03 | 3.98e-02 | 0.1323 |
90634 | N4BP2L1 | P8T-E | Human | Esophagus | ESCC | 4.63e-08 | 2.13e-01 | 0.0889 |
90634 | N4BP2L1 | P9T-E | Human | Esophagus | ESCC | 3.58e-13 | 1.66e-01 | 0.1131 |
90634 | N4BP2L1 | P10T-E | Human | Esophagus | ESCC | 1.33e-02 | 1.59e-02 | 0.116 |
90634 | N4BP2L1 | P11T-E | Human | Esophagus | ESCC | 2.92e-14 | 4.41e-01 | 0.1426 |
90634 | N4BP2L1 | P12T-E | Human | Esophagus | ESCC | 1.53e-06 | 1.90e-01 | 0.1122 |
90634 | N4BP2L1 | P15T-E | Human | Esophagus | ESCC | 1.94e-06 | 6.70e-02 | 0.1149 |
90634 | N4BP2L1 | P16T-E | Human | Esophagus | ESCC | 6.15e-10 | 1.51e-01 | 0.1153 |
90634 | N4BP2L1 | P20T-E | Human | Esophagus | ESCC | 1.75e-06 | 9.09e-02 | 0.1124 |
90634 | N4BP2L1 | P22T-E | Human | Esophagus | ESCC | 2.09e-08 | 7.87e-02 | 0.1236 |
90634 | N4BP2L1 | P23T-E | Human | Esophagus | ESCC | 8.13e-11 | 2.08e-01 | 0.108 |
90634 | N4BP2L1 | P24T-E | Human | Esophagus | ESCC | 1.76e-05 | 1.83e-01 | 0.1287 |
90634 | N4BP2L1 | P26T-E | Human | Esophagus | ESCC | 4.62e-03 | 2.68e-02 | 0.1276 |
90634 | N4BP2L1 | P27T-E | Human | Esophagus | ESCC | 2.45e-05 | 1.04e-01 | 0.1055 |
90634 | N4BP2L1 | P28T-E | Human | Esophagus | ESCC | 7.15e-03 | 7.02e-02 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
N4BP2L1 | SNV | Missense_Mutation | c.85N>A | p.Pro29Thr | p.P29T | Q5TBK1 | protein_coding | tolerated(0.36) | possibly_damaging(0.637) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
N4BP2L1 | SNV | Missense_Mutation | rs754642145 | c.443G>A | p.Arg148His | p.R148H | Q5TBK1 | protein_coding | tolerated(0.52) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
N4BP2L1 | SNV | Missense_Mutation | c.377N>C | p.Met126Thr | p.M126T | Q5TBK1 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DC-6158-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
N4BP2L1 | SNV | Missense_Mutation | c.476N>A | p.Arg159Lys | p.R159K | Q5TBK1 | protein_coding | tolerated(0.06) | possibly_damaging(0.545) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
N4BP2L1 | SNV | Missense_Mutation | novel | c.535G>A | p.Asp179Asn | p.D179N | Q5TBK1 | protein_coding | tolerated(0.51) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | deletion | Frame_Shift_Del | c.483_486delNNNN | p.Ile161MetfsTer11 | p.I161Mfs*11 | Q5TBK1 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
N4BP2L1 | SNV | Missense_Mutation | novel | c.220A>G | p.Thr74Ala | p.T74A | Q5TBK1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | SNV | Missense_Mutation | novel | c.251N>T | p.Ala84Val | p.A84V | Q5TBK1 | protein_coding | tolerated(0.37) | benign(0.023) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
N4BP2L1 | SNV | Missense_Mutation | rs766580917 | c.512N>A | p.Arg171Gln | p.R171Q | Q5TBK1 | protein_coding | tolerated(0.32) | possibly_damaging(0.763) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
N4BP2L1 | SNV | Missense_Mutation | c.308C>G | p.Ala103Gly | p.A103G | Q5TBK1 | protein_coding | deleterious(0.04) | benign(0.279) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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