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Gene: MYO1A |
Gene summary for MYO1A |
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Gene information | Species | Human | Gene symbol | MYO1A | Gene ID | 4640 |
Gene name | myosin IA | |
Gene Alias | BBMI | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B2R643 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4640 | MYO1A | Pat01-B | Human | Stomach | GC | 1.72e-39 | 7.85e-01 | 0.5754 |
4640 | MYO1A | Pat03-B | Human | Stomach | GC | 2.21e-25 | 6.29e-01 | 0.3693 |
4640 | MYO1A | Pat05-B | Human | Stomach | GC | 2.19e-02 | 2.15e-01 | -0.0353 |
4640 | MYO1A | Pat17-B | Human | Stomach | GC | 3.01e-08 | 2.97e-01 | 0.3109 |
4640 | MYO1A | SIM_1 | Human | Stomach | SIM | 2.40e-03 | 2.90e-01 | 0.3573 |
4640 | MYO1A | SIM_2 | Human | Stomach | SIM | 1.23e-02 | 1.44e-01 | 0.3139 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070156 | Stomach | GC | actin filament organization | 67/1159 | 442/18723 | 7.96e-12 | 2.20e-09 | 67 |
GO:00325285 | Stomach | GC | microvillus organization | 13/1159 | 24/18723 | 2.41e-10 | 3.75e-08 | 13 |
GO:00300335 | Stomach | GC | microvillus assembly | 8/1159 | 16/18723 | 1.73e-06 | 7.78e-05 | 8 |
GO:00300485 | Stomach | GC | actin filament-based movement | 22/1159 | 127/18723 | 1.03e-05 | 3.42e-04 | 22 |
GO:00995155 | Stomach | GC | actin filament-based transport | 8/1159 | 21/18723 | 2.07e-05 | 6.33e-04 | 8 |
GO:00300505 | Stomach | GC | vesicle transport along actin filament | 7/1159 | 19/18723 | 8.91e-05 | 1.85e-03 | 7 |
GO:003252841 | Stomach | SIM | microvillus organization | 9/708 | 24/18723 | 1.18e-07 | 9.94e-06 | 9 |
GO:000701541 | Stomach | SIM | actin filament organization | 38/708 | 442/18723 | 2.29e-06 | 1.15e-04 | 38 |
GO:003003341 | Stomach | SIM | microvillus assembly | 5/708 | 16/18723 | 2.35e-04 | 4.64e-03 | 5 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513012 | Stomach | GC | Pathogenic Escherichia coli infection | 43/708 | 197/8465 | 2.99e-09 | 6.39e-08 | 4.50e-08 | 43 |
hsa0513013 | Stomach | GC | Pathogenic Escherichia coli infection | 43/708 | 197/8465 | 2.99e-09 | 6.39e-08 | 4.50e-08 | 43 |
hsa05130101 | Stomach | SIM | Pathogenic Escherichia coli infection | 31/465 | 197/8465 | 8.76e-08 | 1.66e-06 | 1.34e-06 | 31 |
hsa05130111 | Stomach | SIM | Pathogenic Escherichia coli infection | 31/465 | 197/8465 | 8.76e-08 | 1.66e-06 | 1.34e-06 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYO1A | SNV | Missense_Mutation | c.2315N>G | p.Ala772Gly | p.A772G | Q9UBC5 | protein_coding | tolerated(0.91) | benign(0.015) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
MYO1A | SNV | Missense_Mutation | rs571962392 | c.1600N>A | p.Ala534Thr | p.A534T | Q9UBC5 | protein_coding | tolerated(0.08) | benign(0.028) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYO1A | SNV | Missense_Mutation | c.2587C>G | p.Gln863Glu | p.Q863E | Q9UBC5 | protein_coding | tolerated(0.63) | benign(0.015) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MYO1A | SNV | Missense_Mutation | novel | c.733A>G | p.Arg245Gly | p.R245G | Q9UBC5 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MYO1A | SNV | Missense_Mutation | rs749042781 | c.377A>G | p.Glu126Gly | p.E126G | Q9UBC5 | protein_coding | tolerated(0.07) | possibly_damaging(0.871) | TCGA-D8-A1XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
MYO1A | SNV | Missense_Mutation | novel | c.3024N>C | p.Lys1008Asn | p.K1008N | Q9UBC5 | protein_coding | tolerated(0.1) | probably_damaging(0.985) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MYO1A | SNV | Missense_Mutation | rs371875751 | c.984N>T | p.Lys328Asn | p.K328N | Q9UBC5 | protein_coding | tolerated(0.14) | benign(0.019) | TCGA-EW-A1PA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
MYO1A | insertion | Nonsense_Mutation | novel | c.907_908insCATAGTAGATCATTCCAGCATTACCAAGTAGCCCTA | p.Gly303delinsAlaTerTerIleIleProAlaLeuProSerSerProArg | p.G303delinsA**IIPALPSSPR | Q9UBC5 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
MYO1A | insertion | Frame_Shift_Ins | novel | c.905_906insGTTTCCCT | p.Ile302MetfsTer10 | p.I302Mfs*10 | Q9UBC5 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
MYO1A | insertion | Nonsense_Mutation | novel | c.2338_2339insGAGGTAGGCTCTTTTCTTTCTCCCATTTTGTAGTTAAAAAG | p.Tyr780Ter | p.Y780* | Q9UBC5 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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