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Gene: MGAT4A |
Gene summary for MGAT4A |
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Gene information | Species | Human | Gene symbol | MGAT4A | Gene ID | 11320 |
Gene name | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A | |
Gene Alias | GNT-IV | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UM21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11320 | MGAT4A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.02e-17 | -5.58e-01 | 0.0155 |
11320 | MGAT4A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.02e-05 | -2.72e-01 | -0.1464 |
11320 | MGAT4A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.91e-11 | -5.30e-01 | 0.096 |
11320 | MGAT4A | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.17e-07 | -4.95e-01 | 0.0338 |
11320 | MGAT4A | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.17e-16 | -5.15e-01 | 0.0674 |
11320 | MGAT4A | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.34e-08 | -6.00e-01 | 0.0588 |
11320 | MGAT4A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.11e-22 | -5.76e-01 | 0.294 |
11320 | MGAT4A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.89e-09 | -4.20e-01 | 0.3859 |
11320 | MGAT4A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.38e-06 | -6.12e-01 | 0.2585 |
11320 | MGAT4A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.66e-15 | -5.41e-01 | 0.3005 |
11320 | MGAT4A | F007 | Human | Colorectum | FAP | 3.15e-10 | -5.23e-01 | 0.1176 |
11320 | MGAT4A | A002-C-010 | Human | Colorectum | FAP | 1.95e-07 | -3.97e-01 | 0.242 |
11320 | MGAT4A | A001-C-207 | Human | Colorectum | FAP | 3.33e-10 | -4.14e-01 | 0.1278 |
11320 | MGAT4A | A015-C-203 | Human | Colorectum | FAP | 3.06e-27 | -4.75e-01 | -0.1294 |
11320 | MGAT4A | A015-C-204 | Human | Colorectum | FAP | 1.38e-13 | -5.13e-01 | -0.0228 |
11320 | MGAT4A | A014-C-040 | Human | Colorectum | FAP | 2.37e-05 | -4.79e-01 | -0.1184 |
11320 | MGAT4A | A002-C-201 | Human | Colorectum | FAP | 1.30e-26 | -5.75e-01 | 0.0324 |
11320 | MGAT4A | A002-C-203 | Human | Colorectum | FAP | 2.61e-15 | -4.67e-01 | 0.2786 |
11320 | MGAT4A | A001-C-119 | Human | Colorectum | FAP | 1.36e-11 | -5.58e-01 | -0.1557 |
11320 | MGAT4A | A001-C-108 | Human | Colorectum | FAP | 8.35e-22 | -5.09e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0019082 | Colorectum | AD | viral protein processing | 17/3918 | 29/18723 | 1.04e-05 | 2.40e-04 | 17 |
GO:0006487 | Colorectum | AD | protein N-linked glycosylation | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00190802 | Colorectum | MSS | viral gene expression | 41/3467 | 94/18723 | 1.74e-08 | 9.85e-07 | 41 |
GO:00190821 | Colorectum | MSS | viral protein processing | 17/3467 | 29/18723 | 1.81e-06 | 5.70e-05 | 17 |
GO:00064871 | Colorectum | MSS | protein N-linked glycosylation | 23/3467 | 65/18723 | 9.47e-04 | 9.54e-03 | 23 |
GO:00160324 | Colorectum | FAP | viral process | 114/2622 | 415/18723 | 3.00e-13 | 2.63e-10 | 114 |
GO:00190804 | Colorectum | FAP | viral gene expression | 29/2622 | 94/18723 | 2.07e-05 | 5.05e-04 | 29 |
GO:00190822 | Colorectum | FAP | viral protein processing | 11/2622 | 29/18723 | 1.20e-03 | 1.14e-02 | 11 |
GO:00064861 | Colorectum | FAP | protein glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00434131 | Colorectum | FAP | macromolecule glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00700851 | Colorectum | FAP | glycosylation | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:0009101 | Colorectum | FAP | glycoprotein biosynthetic process | 63/2622 | 317/18723 | 2.31e-03 | 1.86e-02 | 63 |
GO:00064872 | Colorectum | FAP | protein N-linked glycosylation | 18/2622 | 65/18723 | 2.85e-03 | 2.19e-02 | 18 |
GO:00160325 | Colorectum | CRC | viral process | 95/2078 | 415/18723 | 3.31e-12 | 3.30e-09 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00510 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa005101 | Colorectum | AD | N-Glycan biosynthesis | 21/2092 | 53/8465 | 1.15e-02 | 4.24e-02 | 2.71e-02 | 21 |
hsa005102 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa00513 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
hsa005103 | Colorectum | MSS | N-Glycan biosynthesis | 20/1875 | 53/8465 | 7.17e-03 | 2.83e-02 | 1.73e-02 | 20 |
hsa005131 | Colorectum | MSS | Various types of N-glycan biosynthesis | 16/1875 | 42/8465 | 1.39e-02 | 4.53e-02 | 2.77e-02 | 16 |
hsa0051023 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa005136 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0051033 | Esophagus | ESCC | N-Glycan biosynthesis | 39/4205 | 53/8465 | 3.26e-04 | 1.15e-03 | 5.89e-04 | 39 |
hsa0051313 | Esophagus | ESCC | Various types of N-glycan biosynthesis | 31/4205 | 42/8465 | 1.23e-03 | 3.78e-03 | 1.93e-03 | 31 |
hsa0051021 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005132 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
hsa0051031 | Liver | HCC | N-Glycan biosynthesis | 40/4020 | 53/8465 | 2.95e-05 | 1.87e-04 | 1.04e-04 | 40 |
hsa005133 | Liver | HCC | Various types of N-glycan biosynthesis | 30/4020 | 42/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MGAT4A | SNV | Missense_Mutation | c.1340N>A | p.Gly447Asp | p.G447D | Q9UM21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MGAT4A | SNV | Missense_Mutation | novel | c.1322N>T | p.Ser441Ile | p.S441I | Q9UM21 | protein_coding | deleterious(0.02) | benign(0.188) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
MGAT4A | insertion | Frame_Shift_Ins | novel | c.1122_1123insA | p.Leu375ThrfsTer4 | p.L375Tfs*4 | Q9UM21 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MGAT4A | insertion | Frame_Shift_Ins | novel | c.259dupT | p.Ser87PhefsTer3 | p.S87Ffs*3 | Q9UM21 | protein_coding | TCGA-W8-A86G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
MGAT4A | SNV | Missense_Mutation | c.501G>T | p.Glu167Asp | p.E167D | Q9UM21 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
MGAT4A | SNV | Missense_Mutation | c.822N>C | p.Lys274Asn | p.K274N | Q9UM21 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MGAT4A | SNV | Missense_Mutation | novel | c.715N>C | p.Asn239His | p.N239H | Q9UM21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MGAT4A | insertion | Frame_Shift_Ins | novel | c.1596_1597insA | p.Ala533SerfsTer7 | p.A533Sfs*7 | Q9UM21 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
MGAT4A | SNV | Missense_Mutation | novel | c.881N>A | p.Gly294Asp | p.G294D | Q9UM21 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MGAT4A | SNV | Missense_Mutation | rs757474576 | c.305N>T | p.Ser102Phe | p.S102F | Q9UM21 | protein_coding | tolerated(0.1) | benign(0.305) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11320 | MGAT4A | DRUGGABLE GENOME | bevacizumab | BEVACIZUMAB | 26222057 | |
11320 | MGAT4A | DRUGGABLE GENOME | cetuximab | CETUXIMAB | 26222057 | |
11320 | MGAT4A | DRUGGABLE GENOME | oxaliplatin | OXALIPLATIN | 26222057 | |
11320 | MGAT4A | DRUGGABLE GENOME | capecitabine | CAPECITABINE | 26222057 |
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