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Gene: MAGEA8 |
Gene summary for MAGEA8 |
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Gene information | Species | Human | Gene symbol | MAGEA8 | Gene ID | 4107 |
Gene name | MAGE family member A8 | |
Gene Alias | CT1.8 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B2R9W4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4107 | MAGEA8 | S014 | Human | Liver | HCC | 4.05e-43 | 1.22e+00 | 0.2254 |
4107 | MAGEA8 | S015 | Human | Liver | HCC | 9.34e-34 | 1.23e+00 | 0.2375 |
4107 | MAGEA8 | S016 | Human | Liver | HCC | 3.86e-45 | 1.27e+00 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA8 | SNV | Missense_Mutation | c.401C>T | p.Thr134Ile | p.T134I | P43361 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A7-A13F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
MAGEA8 | SNV | Missense_Mutation | c.722N>C | p.Val241Ala | p.V241A | P43361 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MAGEA8 | SNV | Missense_Mutation | c.409N>A | p.Glu137Lys | p.E137K | P43361 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAGEA8 | SNV | Missense_Mutation | c.901N>T | p.Arg301Cys | p.R301C | P43361 | protein_coding | deleterious(0.02) | possibly_damaging(0.777) | TCGA-GM-A2DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | PD | |
MAGEA8 | insertion | Nonsense_Mutation | novel | c.563_564insGCCTCCTCTTCCCTGA | p.Tyr189ProfsTer5 | p.Y189Pfs*5 | P43361 | protein_coding | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | ||
MAGEA8 | insertion | Frame_Shift_Ins | novel | c.841_842insT | p.Ala282CysfsTer2 | p.A282Cfs*2 | P43361 | protein_coding | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | ||
MAGEA8 | SNV | Missense_Mutation | novel | c.820T>C | p.Phe274Leu | p.F274L | P43361 | protein_coding | deleterious(0.03) | possibly_damaging(0.533) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MAGEA8 | SNV | Missense_Mutation | c.253G>A | p.Glu85Lys | p.E85K | P43361 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MAGEA8 | SNV | Missense_Mutation | c.253N>A | p.Glu85Lys | p.E85K | P43361 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
MAGEA8 | SNV | Missense_Mutation | rs782267175 | c.361C>T | p.Arg121Cys | p.R121C | P43361 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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