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Gene: LTO1 |
Gene summary for LTO1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LTO1 | Gene ID | 220064 |
Gene name | LTO1 maturation factor of ABCE1 | |
Gene Alias | CIAB1 | |
Cytomap | 11q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | A0A024R5H3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
220064 | LTO1 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 4.66e-01 | 0.082 |
220064 | LTO1 | LZE4T | Human | Esophagus | ESCC | 3.06e-21 | 5.23e-01 | 0.0811 |
220064 | LTO1 | LZE5T | Human | Esophagus | ESCC | 6.95e-12 | 6.30e-01 | 0.0514 |
220064 | LTO1 | LZE7T | Human | Esophagus | ESCC | 3.01e-10 | 4.46e-01 | 0.0667 |
220064 | LTO1 | LZE8T | Human | Esophagus | ESCC | 1.08e-12 | 3.77e-01 | 0.067 |
220064 | LTO1 | LZE20T | Human | Esophagus | ESCC | 3.61e-13 | 4.18e-01 | 0.0662 |
220064 | LTO1 | LZE21D1 | Human | Esophagus | HGIN | 7.28e-11 | 1.02e+00 | 0.0632 |
220064 | LTO1 | LZE22D1 | Human | Esophagus | HGIN | 9.21e-09 | 3.77e-01 | 0.0595 |
220064 | LTO1 | LZE22T | Human | Esophagus | ESCC | 6.43e-20 | 8.93e-01 | 0.068 |
220064 | LTO1 | LZE24T | Human | Esophagus | ESCC | 2.62e-15 | 3.36e-01 | 0.0596 |
220064 | LTO1 | LZE22D3 | Human | Esophagus | HGIN | 4.92e-04 | 5.15e-01 | 0.0653 |
220064 | LTO1 | LZE21T | Human | Esophagus | ESCC | 2.78e-26 | 1.24e+00 | 0.0655 |
220064 | LTO1 | LZE6T | Human | Esophagus | ESCC | 1.71e-05 | 2.51e-01 | 0.0845 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:000641320 | Esophagus | HGIN | translational initiation | 55/2587 | 118/18723 | 7.33e-18 | 2.31e-15 | 55 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:000072318 | Esophagus | HGIN | telomere maintenance | 38/2587 | 131/18723 | 4.38e-06 | 1.42e-04 | 38 |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:00322007 | Esophagus | HGIN | telomere organization | 38/2587 | 159/18723 | 4.23e-04 | 6.39e-03 | 38 |
GO:00974282 | Esophagus | HGIN | protein maturation by iron-sulfur cluster transfer | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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