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Gene: LINC01376 |
Gene summary for LINC01376 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC01376 | Gene ID | 400945 |
| Gene name | long intergenic non-protein coding RNA 1376 | |
| Gene Alias | LINC01376 | |
| Cytomap | 2p24.2-p24.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 400945 | LINC01376 | RNA-P23T2-P23T2-4 | Human | Lung | MIAC | 9.90e-04 | 9.00e-01 | -0.0272 |
| 400945 | LINC01376 | RNA-P3T-P3T-1 | Human | Lung | IAC | 8.87e-03 | 3.59e-01 | 0.1829 |
| 400945 | LINC01376 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.24e-16 | 5.36e-01 | -0.0166 |
| 400945 | LINC01376 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.42e-19 | 5.80e-01 | -0.0132 |
| 400945 | LINC01376 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 8.04e-21 | 5.67e-01 | -0.013 |
| 400945 | LINC01376 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.08e-19 | 5.94e-01 | -0.0121 |
| 400945 | LINC01376 | HTA12-15-2 | Human | Pancreas | PDAC | 4.27e-03 | 2.81e-01 | 0.2315 |
| 400945 | LINC01376 | HTA12-23-1 | Human | Pancreas | PDAC | 1.44e-05 | 5.60e-01 | 0.3405 |
| 400945 | LINC01376 | HTA12-25-1 | Human | Pancreas | PDAC | 7.61e-16 | 8.81e-01 | 0.313 |
| 400945 | LINC01376 | HTA12-26-1 | Human | Pancreas | PDAC | 1.03e-14 | 6.53e-01 | 0.3728 |
| 400945 | LINC01376 | HTA12-29-1 | Human | Pancreas | PDAC | 3.74e-28 | 6.32e-01 | 0.3722 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Thyroid | PTC |  |
| Thyroid | goiters |  |
| Thyroid | ATC |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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