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Gene: LINC00278 |
Gene summary for LINC00278 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LINC00278 | Gene ID | 100873962 |
Gene name | long intergenic non-protein coding RNA 278 | |
Gene Alias | NCRNA00278 | |
Cytomap | Yp11.2 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100873962 | LINC00278 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.42e-06 | -3.88e-01 | 0.0155 |
100873962 | LINC00278 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.72e-05 | -5.04e-01 | -0.1808 |
100873962 | LINC00278 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.77e-12 | -6.57e-01 | -0.0811 |
100873962 | LINC00278 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.06e-27 | -6.52e-01 | -0.1954 |
100873962 | LINC00278 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.11e-07 | -4.75e-01 | 0.096 |
100873962 | LINC00278 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.50e-06 | -6.57e-01 | 0.0528 |
100873962 | LINC00278 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.68e-15 | -6.57e-01 | 0.0338 |
100873962 | LINC00278 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.82e-15 | -4.27e-01 | 0.294 |
100873962 | LINC00278 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.81e-13 | -6.57e-01 | 0.281 |
100873962 | LINC00278 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.58e-10 | -6.57e-01 | 0.2585 |
100873962 | LINC00278 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.24e-19 | -5.24e-01 | 0.3005 |
100873962 | LINC00278 | F007 | Human | Colorectum | FAP | 1.58e-16 | -6.57e-01 | 0.1176 |
100873962 | LINC00278 | A002-C-010 | Human | Colorectum | FAP | 8.59e-39 | -6.57e-01 | 0.242 |
100873962 | LINC00278 | A015-C-203 | Human | Colorectum | FAP | 2.30e-41 | -6.57e-01 | -0.1294 |
100873962 | LINC00278 | A015-C-204 | Human | Colorectum | FAP | 7.16e-23 | -6.57e-01 | -0.0228 |
100873962 | LINC00278 | A014-C-040 | Human | Colorectum | FAP | 2.90e-08 | -6.57e-01 | -0.1184 |
100873962 | LINC00278 | A002-C-201 | Human | Colorectum | FAP | 5.54e-31 | -6.57e-01 | 0.0324 |
100873962 | LINC00278 | A002-C-203 | Human | Colorectum | FAP | 2.85e-36 | -6.57e-01 | 0.2786 |
100873962 | LINC00278 | A001-C-119 | Human | Colorectum | FAP | 8.91e-11 | -5.08e-01 | -0.1557 |
100873962 | LINC00278 | A001-C-108 | Human | Colorectum | FAP | 1.31e-16 | -3.68e-01 | -0.0272 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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