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Gene: LINC00261 |
Gene summary for LINC00261 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC00261 | Gene ID | 140828 |
| Gene name | long intergenic non-protein coding RNA 261 | |
| Gene Alias | ALIEN | |
| Cytomap | 20p11.21 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 140828 | LINC00261 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.62e-11 | 6.30e-01 | -0.1088 |
| 140828 | LINC00261 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.91e-05 | 2.57e-01 | -0.1207 |
| 140828 | LINC00261 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.58e-25 | 9.00e-01 | -0.1464 |
| 140828 | LINC00261 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-04 | 1.64e-01 | -0.1001 |
| 140828 | LINC00261 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.17e-02 | 2.15e-01 | -0.0842 |
| 140828 | LINC00261 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-03 | 1.18e-01 | 0.3859 |
| 140828 | LINC00261 | HCC1_Meng | Human | Liver | HCC | 3.01e-65 | 1.55e-02 | 0.0246 |
| 140828 | LINC00261 | cirrhotic1 | Human | Liver | Cirrhotic | 1.39e-09 | 9.18e-02 | 0.0202 |
| 140828 | LINC00261 | cirrhotic2 | Human | Liver | Cirrhotic | 4.08e-12 | 1.69e-01 | 0.0201 |
| 140828 | LINC00261 | cirrhotic3 | Human | Liver | Cirrhotic | 1.60e-02 | -7.45e-03 | 0.0215 |
| 140828 | LINC00261 | HCC1 | Human | Liver | HCC | 6.74e-09 | 4.15e+00 | 0.5336 |
| 140828 | LINC00261 | HCC2 | Human | Liver | HCC | 1.34e-08 | 3.25e+00 | 0.5341 |
| 140828 | LINC00261 | Pt13.b | Human | Liver | HCC | 4.38e-06 | -8.33e-02 | 0.0251 |
| 140828 | LINC00261 | Pt13.c | Human | Liver | HCC | 3.88e-03 | -2.49e-01 | 0.0076 |
| 140828 | LINC00261 | Pt14.a | Human | Liver | HCC | 5.20e-04 | 2.69e-01 | 0.0169 |
| 140828 | LINC00261 | Pt14.b | Human | Liver | HCC | 1.33e-06 | 3.29e-01 | 0.018 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Thyroid | PTC |  |
| Thyroid | goiters |  |
| Thyroid | ATC |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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