Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0071496 | Colorectum | AD | cellular response to external stimulus | 94/3918 | 320/18723 | 1.98e-04 | 2.64e-03 | 94 |
GO:0009267 | Colorectum | AD | cellular response to starvation | 51/3918 | 156/18723 | 3.90e-04 | 4.44e-03 | 51 |
GO:0031668 | Colorectum | AD | cellular response to extracellular stimulus | 71/3918 | 246/18723 | 1.86e-03 | 1.52e-02 | 71 |
GO:0031669 | Colorectum | AD | cellular response to nutrient levels | 63/3918 | 215/18723 | 2.19e-03 | 1.73e-02 | 63 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00507081 | Colorectum | SER | regulation of protein secretion | 63/2897 | 268/18723 | 3.42e-04 | 5.39e-03 | 63 |
GO:00093061 | Colorectum | SER | protein secretion | 79/2897 | 359/18723 | 5.99e-04 | 8.19e-03 | 79 |
GO:00355921 | Colorectum | SER | establishment of protein localization to extracellular region | 79/2897 | 360/18723 | 6.54e-04 | 8.77e-03 | 79 |
GO:00716921 | Colorectum | SER | protein localization to extracellular region | 80/2897 | 368/18723 | 8.13e-04 | 1.01e-02 | 80 |
GO:00425941 | Colorectum | SER | response to starvation | 47/2897 | 197/18723 | 1.31e-03 | 1.45e-02 | 47 |
GO:00714961 | Colorectum | SER | cellular response to external stimulus | 70/2897 | 320/18723 | 1.40e-03 | 1.53e-02 | 70 |
GO:00092671 | Colorectum | SER | cellular response to starvation | 38/2897 | 156/18723 | 2.45e-03 | 2.32e-02 | 38 |
GO:00316681 | Colorectum | SER | cellular response to extracellular stimulus | 54/2897 | 246/18723 | 4.26e-03 | 3.45e-02 | 54 |
GO:00316691 | Colorectum | SER | cellular response to nutrient levels | 48/2897 | 215/18723 | 4.82e-03 | 3.78e-02 | 48 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04915 | Colorectum | SER | Estrogen signaling pathway | 38/1580 | 138/8465 | 6.51e-03 | 3.68e-02 | 2.67e-02 | 38 |
hsa049151 | Colorectum | SER | Estrogen signaling pathway | 38/1580 | 138/8465 | 6.51e-03 | 3.68e-02 | 2.67e-02 | 38 |
hsa049152 | Colorectum | MSS | Estrogen signaling pathway | 48/1875 | 138/8465 | 4.23e-04 | 3.08e-03 | 1.89e-03 | 48 |
hsa049153 | Colorectum | MSS | Estrogen signaling pathway | 48/1875 | 138/8465 | 4.23e-04 | 3.08e-03 | 1.89e-03 | 48 |
hsa0491512 | Stomach | GC | Estrogen signaling pathway | 23/708 | 138/8465 | 1.02e-03 | 7.44e-03 | 5.23e-03 | 23 |
hsa0491513 | Stomach | GC | Estrogen signaling pathway | 23/708 | 138/8465 | 1.02e-03 | 7.44e-03 | 5.23e-03 | 23 |
hsa0491521 | Stomach | CAG with IM | Estrogen signaling pathway | 21/640 | 138/8465 | 1.53e-03 | 1.01e-02 | 7.10e-03 | 21 |
hsa0491531 | Stomach | CAG with IM | Estrogen signaling pathway | 21/640 | 138/8465 | 1.53e-03 | 1.01e-02 | 7.10e-03 | 21 |
hsa049158 | Stomach | WIM | Estrogen signaling pathway | 16/284 | 138/8465 | 1.41e-05 | 1.72e-04 | 1.37e-04 | 16 |
hsa049159 | Stomach | WIM | Estrogen signaling pathway | 16/284 | 138/8465 | 1.41e-05 | 1.72e-04 | 1.37e-04 | 16 |
hsa0491510 | Stomach | SIM | Estrogen signaling pathway | 20/465 | 138/8465 | 5.98e-05 | 6.73e-04 | 5.40e-04 | 20 |
hsa0491511 | Stomach | SIM | Estrogen signaling pathway | 20/465 | 138/8465 | 5.98e-05 | 6.73e-04 | 5.40e-04 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT20 | SNV | Missense_Mutation | novel | c.484N>A | p.Glu162Lys | p.E162K | P35900 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KRT20 | SNV | Missense_Mutation | | c.245N>T | p.Ala82Val | p.A82V | P35900 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT20 | SNV | Missense_Mutation | | c.1010N>A | p.Ala337Asp | p.A337D | P35900 | protein_coding | tolerated(0.14) | benign(0.011) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT20 | insertion | Frame_Shift_Ins | rs747468237 | c.73_74insCTGTTTATATAGGAAGGGGT | p.Gly25AlafsTer36 | p.G25Afs*36 | P35900 | protein_coding | | | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
KRT20 | insertion | Frame_Shift_Ins | rs747468237 | c.73_74insCTGTTTATATAGGAAGGGGT | p.Gly25AlafsTer36 | p.G25Afs*36 | P35900 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT20 | insertion | Frame_Shift_Ins | novel | c.724_727dupATGA | p.Arg243AsnfsTer6 | p.R243Nfs*6 | P35900 | protein_coding | | | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
KRT20 | SNV | Missense_Mutation | rs754776993 | c.118G>A | p.Gly40Arg | p.G40R | P35900 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KRT20 | SNV | Missense_Mutation | | c.373N>A | p.Glu125Lys | p.E125K | P35900 | protein_coding | tolerated(0.08) | benign(0.018) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KRT20 | SNV | Missense_Mutation | | c.643N>A | p.Leu215Ile | p.L215I | P35900 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT20 | SNV | Missense_Mutation | rs371817674 | c.1210N>A | p.Val404Met | p.V404M | P35900 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |