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Gene: IGFBP4 |
Gene summary for IGFBP4 |
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Gene information | Species | Human | Gene symbol | IGFBP4 | Gene ID | 3487 |
Gene name | insulin like growth factor binding protein 4 | |
Gene Alias | BP-4 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R1U8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3487 | IGFBP4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.34e-06 | 3.10e-01 | 0.0155 |
3487 | IGFBP4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.39e-19 | 7.86e-01 | -0.1808 |
3487 | IGFBP4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.24e-14 | 6.01e-01 | -0.0811 |
3487 | IGFBP4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.95e-07 | 4.17e-01 | -0.1088 |
3487 | IGFBP4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.30e-45 | 1.02e+00 | -0.1954 |
3487 | IGFBP4 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-02 | 8.14e-01 | -0.2602 |
3487 | IGFBP4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.77e-17 | 8.18e-01 | -0.1207 |
3487 | IGFBP4 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.13e-16 | 8.76e-01 | -0.1526 |
3487 | IGFBP4 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.27e-25 | 8.55e-01 | -0.1464 |
3487 | IGFBP4 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.21e-12 | 5.94e-01 | -0.1001 |
3487 | IGFBP4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.81e-17 | 6.82e-01 | -0.059 |
3487 | IGFBP4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.63e-06 | 7.79e-01 | -0.1706 |
3487 | IGFBP4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.12e-04 | 6.30e-01 | -0.2061 |
3487 | IGFBP4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.77e-08 | 7.12e-01 | -0.1462 |
3487 | IGFBP4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-15 | 8.64e-01 | -0.0842 |
3487 | IGFBP4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.70e-03 | 4.51e-01 | -0.0179 |
3487 | IGFBP4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.35e-10 | 4.90e-01 | 0.096 |
3487 | IGFBP4 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.96e-04 | 6.57e-01 | 0.0451 |
3487 | IGFBP4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.27e-05 | 4.63e-01 | 0.0528 |
3487 | IGFBP4 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.10e-08 | 8.84e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0006006 | Colorectum | AD | glucose metabolic process | 62/3918 | 196/18723 | 2.76e-04 | 3.39e-03 | 62 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0006109 | Colorectum | AD | regulation of carbohydrate metabolic process | 55/3918 | 178/18723 | 1.10e-03 | 1.01e-02 | 55 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00301111 | Colorectum | SER | regulation of Wnt signaling pathway | 75/2897 | 328/18723 | 2.47e-04 | 4.20e-03 | 75 |
GO:00015581 | Colorectum | SER | regulation of cell growth | 90/2897 | 414/18723 | 4.00e-04 | 6.02e-03 | 90 |
GO:00193181 | Colorectum | SER | hexose metabolic process | 56/2897 | 237/18723 | 6.19e-04 | 8.42e-03 | 56 |
GO:0048009 | Colorectum | SER | insulin-like growth factor receptor signaling pathway | 14/2897 | 37/18723 | 7.80e-04 | 9.87e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGFBP4 | SNV | Missense_Mutation | c.529N>A | p.Glu177Lys | p.E177K | P22692 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
IGFBP4 | insertion | Nonsense_Mutation | novel | c.382_383insAAGCCGAAGAA | p.Phe128Ter | p.F128* | P22692 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
IGFBP4 | insertion | In_Frame_Ins | novel | c.383_384insCCC | p.Phe128_Ser129insPro | p.F128_S129insP | P22692 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
IGFBP4 | SNV | Missense_Mutation | rs745961147 | c.482C>T | p.Ala161Val | p.A161V | P22692 | protein_coding | tolerated(0.52) | benign(0) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IGFBP4 | SNV | Missense_Mutation | c.617G>A | p.Arg206His | p.R206H | P22692 | protein_coding | tolerated(0.1) | probably_damaging(0.963) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IGFBP4 | SNV | Missense_Mutation | novel | c.740T>G | p.Leu247Arg | p.L247R | P22692 | protein_coding | tolerated(0.05) | probably_damaging(0.992) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGFBP4 | SNV | Missense_Mutation | c.673A>G | p.Lys225Glu | p.K225E | P22692 | protein_coding | tolerated(0.1) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IGFBP4 | deletion | Frame_Shift_Del | rs778799414 | c.123delC | p.Val42TrpfsTer52 | p.V42Wfs*52 | P22692 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
IGFBP4 | deletion | Frame_Shift_Del | rs778799414 | c.117delN | p.Val42TrpfsTer52 | p.V42Wfs*52 | P22692 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
IGFBP4 | SNV | Missense_Mutation | rs755831062 | c.430N>A | p.Ala144Thr | p.A144T | P22692 | protein_coding | tolerated(0.18) | benign(0.129) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3487 | IGFBP4 | DRUGGABLE GENOME | PMSG | 9258879 |
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