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Gene: HOXC9 |
Gene summary for HOXC9 |
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Gene information | Species | Human | Gene symbol | HOXC9 | Gene ID | 3225 |
Gene name | homeobox C9 | |
Gene Alias | HOX3 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A024RAZ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3225 | HOXC9 | LZE24T | Human | Esophagus | ESCC | 9.41e-10 | 2.07e-01 | 0.0596 |
3225 | HOXC9 | P2T-E | Human | Esophagus | ESCC | 1.07e-34 | 6.15e-01 | 0.1177 |
3225 | HOXC9 | P8T-E | Human | Esophagus | ESCC | 6.59e-07 | 1.28e-01 | 0.0889 |
3225 | HOXC9 | P9T-E | Human | Esophagus | ESCC | 5.37e-03 | 6.17e-02 | 0.1131 |
3225 | HOXC9 | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 9.71e-02 | 0.116 |
3225 | HOXC9 | P12T-E | Human | Esophagus | ESCC | 1.75e-12 | 3.19e-01 | 0.1122 |
3225 | HOXC9 | P15T-E | Human | Esophagus | ESCC | 1.73e-02 | 1.38e-01 | 0.1149 |
3225 | HOXC9 | P16T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.05e-01 | 0.1153 |
3225 | HOXC9 | P20T-E | Human | Esophagus | ESCC | 8.99e-07 | 9.55e-02 | 0.1124 |
3225 | HOXC9 | P21T-E | Human | Esophagus | ESCC | 7.90e-03 | 8.32e-02 | 0.1617 |
3225 | HOXC9 | P22T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.24e-01 | 0.1236 |
3225 | HOXC9 | P24T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.76e-01 | 0.1287 |
3225 | HOXC9 | P26T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.36e-01 | 0.1276 |
3225 | HOXC9 | P27T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.01e-01 | 0.1055 |
3225 | HOXC9 | P28T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.72e-01 | 0.1149 |
3225 | HOXC9 | P32T-E | Human | Esophagus | ESCC | 2.58e-08 | 1.56e-01 | 0.1666 |
3225 | HOXC9 | P37T-E | Human | Esophagus | ESCC | 7.14e-09 | 1.79e-01 | 0.1371 |
3225 | HOXC9 | P48T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.21e-01 | 0.0959 |
3225 | HOXC9 | P52T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.12e-01 | 0.1555 |
3225 | HOXC9 | P54T-E | Human | Esophagus | ESCC | 3.13e-15 | 3.22e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
GO:00487053 | Thyroid | ATC | skeletal system morphogenesis | 101/6293 | 220/18723 | 9.48e-05 | 6.93e-04 | 101 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXC9 | SNV | Missense_Mutation | novel | c.727C>G | p.Arg243Gly | p.R243G | P31274 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXC9 | SNV | Missense_Mutation | rs781692385 | c.572N>T | p.Ser191Phe | p.S191F | P31274 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
HOXC9 | SNV | Missense_Mutation | c.271C>T | p.Arg91Cys | p.R91C | P31274 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HOXC9 | SNV | Missense_Mutation | c.700N>T | p.Arg234Trp | p.R234W | P31274 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HOXC9 | SNV | Missense_Mutation | rs749476187 | c.586N>T | p.Arg196Cys | p.R196C | P31274 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXC9 | SNV | Missense_Mutation | rs762217624 | c.643A>G | p.Met215Val | p.M215V | P31274 | protein_coding | deleterious(0.01) | probably_damaging(0.919) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXC9 | SNV | Missense_Mutation | novel | c.683N>C | p.Val228Ala | p.V228A | P31274 | protein_coding | tolerated(0.34) | benign(0.065) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HOXC9 | SNV | Missense_Mutation | novel | c.166N>A | p.Ala56Thr | p.A56T | P31274 | protein_coding | tolerated(0.1) | possibly_damaging(0.564) | TCGA-AJ-A3BD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
HOXC9 | SNV | Missense_Mutation | novel | c.582N>T | p.Lys194Asn | p.K194N | P31274 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOXC9 | SNV | Missense_Mutation | c.67N>A | p.Leu23Ile | p.L23I | P31274 | protein_coding | tolerated(0.12) | benign(0.02) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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