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Gene: HNRNPUL2 |
Gene summary for HNRNPUL2 |
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Gene information | Species | Human | Gene symbol | HNRNPUL2 | Gene ID | 221092 |
Gene name | heterogeneous nuclear ribonucleoprotein U like 2 | |
Gene Alias | HNRPUL2 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q1KMD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221092 | HNRNPUL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.81e-06 | 1.64e-01 | 0.0155 |
221092 | HNRNPUL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.70e-09 | 2.66e-01 | -0.1808 |
221092 | HNRNPUL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.92e-17 | 4.41e-01 | -0.0811 |
221092 | HNRNPUL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 2.98e-01 | -0.1088 |
221092 | HNRNPUL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.06e-36 | 5.88e-01 | -0.1954 |
221092 | HNRNPUL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.05e-01 | -0.2602 |
221092 | HNRNPUL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 6.10e-01 | -0.2196 |
221092 | HNRNPUL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.09e-01 | -0.1207 |
221092 | HNRNPUL2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 2.71e-01 | -0.1526 |
221092 | HNRNPUL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-22 | 4.18e-01 | -0.1464 |
221092 | HNRNPUL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.35e-15 | 2.67e-01 | -0.1001 |
221092 | HNRNPUL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.12e-21 | 5.14e-01 | -0.059 |
221092 | HNRNPUL2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.56e-01 | -0.1706 |
221092 | HNRNPUL2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | -0.1462 |
221092 | HNRNPUL2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.84e-01 | -0.0842 |
221092 | HNRNPUL2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 3.05e-01 | -0.0179 |
221092 | HNRNPUL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.09e-17 | 3.70e-01 | 0.096 |
221092 | HNRNPUL2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.84e-10 | 4.66e-01 | 0.0446 |
221092 | HNRNPUL2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.79e-04 | 4.04e-01 | 0.0451 |
221092 | HNRNPUL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 1.83e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.2089G>A | p.Asp697Asn | p.D697N | Q1KMD3 | protein_coding | tolerated(0.33) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
HNRNPUL2 | SNV | Missense_Mutation | rs745497599 | c.2011N>T | p.Arg671Trp | p.R671W | Q1KMD3 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.1669N>T | p.Arg557Trp | p.R557W | Q1KMD3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
HNRNPUL2 | insertion | Frame_Shift_Ins | novel | c.1505_1506insCATCCCAA | p.Glu502AspfsTer13 | p.E502Dfs*13 | Q1KMD3 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
HNRNPUL2 | insertion | In_Frame_Ins | novel | c.1503_1504insTTGCTGCCTTTAGTTCCT | p.Pro501_Glu502insLeuLeuProLeuValPro | p.P501_E502insLLPLVP | Q1KMD3 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
HNRNPUL2 | insertion | Nonsense_Mutation | novel | c.737_738insTTAAAATACACACAGAAATAAATAGTAATTACACTAGGCATTTG | p.Asn247Ter | p.N247* | Q1KMD3 | protein_coding | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
HNRNPUL2 | SNV | Missense_Mutation | novel | c.2015C>T | p.Ala672Val | p.A672V | Q1KMD3 | protein_coding | tolerated(0.41) | probably_damaging(0.935) | TCGA-VS-A8QH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD |
HNRNPUL2 | SNV | Missense_Mutation | c.1112N>C | p.Glu371Ala | p.E371A | Q1KMD3 | protein_coding | deleterious(0.02) | possibly_damaging(0.76) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HNRNPUL2 | SNV | Missense_Mutation | rs761674867 | c.971G>A | p.Arg324His | p.R324H | Q1KMD3 | protein_coding | tolerated(0.2) | benign(0.322) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPUL2 | SNV | Missense_Mutation | c.959N>C | p.Val320Ala | p.V320A | Q1KMD3 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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