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Gene: HLTF |
Gene summary for HLTF |
Gene summary. |
Gene information | Species | Human | Gene symbol | HLTF | Gene ID | 6596 |
Gene name | helicase like transcription factor | |
Gene Alias | HIP116 | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0C4DGA6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6596 | HLTF | LZE2T | Human | Esophagus | ESCC | 5.56e-08 | 1.27e+00 | 0.082 |
6596 | HLTF | LZE3D | Human | Esophagus | HGIN | 3.05e-02 | 4.48e-01 | 0.0668 |
6596 | HLTF | LZE4T | Human | Esophagus | ESCC | 1.25e-17 | 6.15e-01 | 0.0811 |
6596 | HLTF | LZE7T | Human | Esophagus | ESCC | 4.33e-16 | 9.20e-01 | 0.0667 |
6596 | HLTF | LZE8T | Human | Esophagus | ESCC | 1.10e-11 | 3.39e-01 | 0.067 |
6596 | HLTF | LZE20T | Human | Esophagus | ESCC | 5.34e-04 | 1.60e-01 | 0.0662 |
6596 | HLTF | LZE22T | Human | Esophagus | ESCC | 2.33e-04 | 3.25e-01 | 0.068 |
6596 | HLTF | LZE24T | Human | Esophagus | ESCC | 1.03e-15 | 5.50e-01 | 0.0596 |
6596 | HLTF | LZE6T | Human | Esophagus | ESCC | 3.99e-02 | 4.40e-01 | 0.0845 |
6596 | HLTF | P1T-E | Human | Esophagus | ESCC | 4.04e-07 | 5.33e-01 | 0.0875 |
6596 | HLTF | P2T-E | Human | Esophagus | ESCC | 2.41e-78 | 1.57e+00 | 0.1177 |
6596 | HLTF | P4T-E | Human | Esophagus | ESCC | 1.77e-24 | 5.87e-01 | 0.1323 |
6596 | HLTF | P5T-E | Human | Esophagus | ESCC | 1.72e-41 | 8.86e-01 | 0.1327 |
6596 | HLTF | P8T-E | Human | Esophagus | ESCC | 9.44e-23 | 4.90e-01 | 0.0889 |
6596 | HLTF | P9T-E | Human | Esophagus | ESCC | 1.21e-06 | 2.28e-01 | 0.1131 |
6596 | HLTF | P10T-E | Human | Esophagus | ESCC | 4.14e-53 | 9.39e-01 | 0.116 |
6596 | HLTF | P11T-E | Human | Esophagus | ESCC | 5.77e-16 | 4.65e-01 | 0.1426 |
6596 | HLTF | P12T-E | Human | Esophagus | ESCC | 8.87e-27 | 5.46e-01 | 0.1122 |
6596 | HLTF | P15T-E | Human | Esophagus | ESCC | 5.49e-39 | 8.74e-01 | 0.1149 |
6596 | HLTF | P16T-E | Human | Esophagus | ESCC | 2.96e-75 | 1.15e+00 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | |
Thyroid | goiters | |
Thyroid | ATC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HLTF | SNV | Missense_Mutation | c.3000N>G | p.Ile1000Met | p.I1000M | Q14527 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-A2-A0T1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | herceptin | SD | |
HLTF | SNV | Missense_Mutation | c.952C>G | p.Leu318Val | p.L318V | Q14527 | protein_coding | deleterious(0.01) | possibly_damaging(0.848) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
HLTF | SNV | Missense_Mutation | rs146224624 | c.2030T>C | p.Ile677Thr | p.I677T | Q14527 | protein_coding | tolerated(0.05) | benign(0.113) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | rs746982688 | c.1013N>G | p.Ser338Cys | p.S338C | Q14527 | protein_coding | tolerated(0.1) | possibly_damaging(0.526) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HLTF | SNV | Missense_Mutation | novel | c.1378N>T | p.Ala460Ser | p.A460S | Q14527 | protein_coding | tolerated(0.71) | benign(0.031) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HLTF | insertion | Frame_Shift_Ins | novel | c.1214_1215insTGTTTTTTTGTTTGTTTGTTTGT | p.Ser406ValfsTer8 | p.S406Vfs*8 | Q14527 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
HLTF | insertion | In_Frame_Ins | novel | c.1212_1213insTCAGCAGAT | p.Glu404_Thr405insSerAlaAsp | p.E404_T405insSAD | Q14527 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
HLTF | SNV | Missense_Mutation | rs773811328 | c.1151G>A | p.Arg384His | p.R384H | Q14527 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HLTF | SNV | Missense_Mutation | c.1454N>T | p.Ser485Phe | p.S485F | Q14527 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HLTF | SNV | Missense_Mutation | novel | c.2441N>T | p.Pro814Leu | p.P814L | Q14527 | protein_coding | tolerated(0.5) | benign(0.023) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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