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Gene: HIGD1B |
Gene summary for HIGD1B |
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Gene information | Species | Human | Gene symbol | HIGD1B | Gene ID | 51751 |
Gene name | HIG1 hypoxia inducible domain family member 1B | |
Gene Alias | CLST11240 | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9P298 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51751 | HIGD1B | Pt13.a | Human | Liver | HCC | 2.96e-09 | 3.67e-01 | 0.021 |
51751 | HIGD1B | Pt13.b | Human | Liver | HCC | 1.39e-36 | 8.48e-01 | 0.0251 |
51751 | HIGD1B | Pt13.c | Human | Liver | HCC | 8.10e-05 | 3.87e-01 | 0.0076 |
51751 | HIGD1B | Pt14.b | Human | Liver | HCC | 2.32e-06 | 5.62e-01 | 0.018 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIGD1B | SNV | Missense_Mutation | rs751484914 | c.16N>T | p.Arg6Cys | p.R6C | Q9P298 | protein_coding | deleterious(0.03) | benign(0.132) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIGD1B | SNV | Missense_Mutation | rs762836154 | c.224N>T | p.Ala75Val | p.A75V | Q9P298 | protein_coding | tolerated(0.06) | benign(0.191) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HIGD1B | SNV | Missense_Mutation | novel | c.4N>C | p.Ser2Pro | p.S2P | Q9P298 | protein_coding | deleterious(0.02) | possibly_damaging(0.855) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIGD1B | SNV | Missense_Mutation | novel | c.94N>A | p.Pro32Thr | p.P32T | Q9P298 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIGD1B | deletion | In_Frame_Del | novel | c.256_258delAGC | p.Ser86del | p.S86del | Q9P298 | protein_coding | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HIGD1B | SNV | Missense_Mutation | novel | c.272G>A | p.Arg91Lys | p.R91K | Q9P298 | protein_coding | tolerated(0.88) | benign(0) | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HIGD1B | SNV | Missense_Mutation | c.235N>C | p.Gly79Arg | p.G79R | Q9P298 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4H5-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | doxifluridine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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