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Gene: HBQ1 |
Gene summary for HBQ1 |
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Gene information | Species | Human | Gene symbol | HBQ1 | Gene ID | 3049 |
Gene name | hemoglobin subunit theta 1 | |
Gene Alias | HBQ | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A1K0GUV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3049 | HBQ1 | S014 | Human | Liver | HCC | 1.38e-20 | 6.02e-01 | 0.2254 |
3049 | HBQ1 | S015 | Human | Liver | HCC | 4.55e-16 | 7.75e-01 | 0.2375 |
3049 | HBQ1 | S016 | Human | Liver | HCC | 1.18e-15 | 6.17e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:199074812 | Liver | HCC | cellular detoxification | 70/7958 | 116/18723 | 7.87e-05 | 7.02e-04 | 70 |
GO:009723712 | Liver | HCC | cellular response to toxic substance | 74/7958 | 124/18723 | 8.36e-05 | 7.36e-04 | 74 |
GO:009875412 | Liver | HCC | detoxification | 87/7958 | 152/18723 | 1.70e-04 | 1.35e-03 | 87 |
GO:009886912 | Liver | HCC | cellular oxidant detoxification | 59/7958 | 101/18723 | 9.00e-04 | 5.31e-03 | 59 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HBQ1 | SNV | Missense_Mutation | novel | c.404N>T | p.Ser135Leu | p.S135L | P09105 | protein_coding | tolerated(0.78) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HBQ1 | SNV | Missense_Mutation | novel | c.349G>A | p.Asp117Asn | p.D117N | P09105 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HBQ1 | SNV | Missense_Mutation | c.335N>A | p.Arg112Gln | p.R112Q | P09105 | protein_coding | tolerated(0.59) | benign(0.355) | TCGA-CD-8528-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | |
HBQ1 | SNV | Missense_Mutation | c.391N>G | p.Ser131Gly | p.S131G | P09105 | protein_coding | tolerated(0.18) | benign(0) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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