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Gene: HABP2 |
Gene summary for HABP2 |
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Gene information | Species | Human | Gene symbol | HABP2 | Gene ID | 3026 |
Gene name | hyaluronan binding protein 2 | |
Gene Alias | FSAP | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q14520 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3026 | HABP2 | S43 | Human | Liver | Cirrhotic | 1.97e-15 | 1.76e-01 | -0.0187 |
3026 | HABP2 | HCC1_Meng | Human | Liver | HCC | 1.07e-69 | 7.16e-02 | 0.0246 |
3026 | HABP2 | HCC2_Meng | Human | Liver | HCC | 1.80e-10 | -2.78e-01 | 0.0107 |
3026 | HABP2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.90e-02 | -1.74e-03 | 0.0202 |
3026 | HABP2 | cirrhotic2 | Human | Liver | Cirrhotic | 5.19e-08 | 1.47e-01 | 0.0201 |
3026 | HABP2 | HCC2 | Human | Liver | HCC | 2.23e-14 | 4.25e+00 | 0.5341 |
3026 | HABP2 | HCC5 | Human | Liver | HCC | 7.82e-07 | 6.45e-01 | 0.4932 |
3026 | HABP2 | Pt13.a | Human | Liver | HCC | 6.33e-06 | -2.66e-01 | 0.021 |
3026 | HABP2 | S014 | Human | Liver | HCC | 2.91e-04 | -3.19e-01 | 0.2254 |
3026 | HABP2 | S015 | Human | Liver | HCC | 1.24e-02 | -3.23e-01 | 0.2375 |
3026 | HABP2 | S016 | Human | Liver | HCC | 7.69e-10 | -3.34e-01 | 0.2243 |
3026 | HABP2 | S027 | Human | Liver | HCC | 3.13e-17 | 2.24e+00 | 0.2446 |
3026 | HABP2 | S028 | Human | Liver | HCC | 4.42e-29 | 1.97e+00 | 0.2503 |
3026 | HABP2 | S029 | Human | Liver | HCC | 1.41e-34 | 2.35e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HABP2 | insertion | Nonsense_Mutation | novel | c.996_997insGACAAGAAAAAACTACATTGTTAATTCTATAGACTTGCTTTATGT | p.Gln332_Ser333insAspLysLysLysLeuHisCysTerPheTyrArgLeuAlaLeuCys | p.Q332_S333insDKKKLHC*FYRLALC | Q14520 | protein_coding | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | ||
HABP2 | insertion | Frame_Shift_Ins | novel | c.357_358insAAGC | p.Cys120LysfsTer21 | p.C120Kfs*21 | Q14520 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
HABP2 | insertion | In_Frame_Ins | novel | c.358_359insGGATTCGGGCTGCTCTAGCAACCATCTTACTTC | p.Cys120delinsTrpIleArgAlaAlaLeuAlaThrIleLeuLeuArg | p.C120delinsWIRAALATILLR | Q14520 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
HABP2 | SNV | Missense_Mutation | rs778461056 | c.1001N>T | p.Ser334Leu | p.S334L | Q14520 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
HABP2 | SNV | Missense_Mutation | novel | c.1255N>T | p.Pro419Ser | p.P419S | Q14520 | protein_coding | tolerated(0.1) | possibly_damaging(0.795) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HABP2 | SNV | Missense_Mutation | c.1222N>A | p.Pro408Thr | p.P408T | Q14520 | protein_coding | tolerated(0.11) | possibly_damaging(0.872) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HABP2 | SNV | Missense_Mutation | c.466N>T | p.Pro156Ser | p.P156S | Q14520 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HABP2 | SNV | Missense_Mutation | novel | c.376C>A | p.Leu126Ile | p.L126I | Q14520 | protein_coding | tolerated(0.08) | benign(0.243) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HABP2 | SNV | Missense_Mutation | c.587N>C | p.Val196Ala | p.V196A | Q14520 | protein_coding | tolerated(0.63) | benign(0.257) | TCGA-AF-4110-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | SD | |
HABP2 | SNV | Missense_Mutation | novel | c.1678N>C | p.Phe560Leu | p.F560L | Q14520 | protein_coding | tolerated_low_confidence(0.11) | benign(0) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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