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Gene: GZMH |
Gene summary for GZMH |
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Gene information | Species | Human | Gene symbol | GZMH | Gene ID | 2999 |
Gene name | granzyme H | |
Gene Alias | CCP-X | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P20718 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2999 | GZMH | C21 | Human | Oral cavity | OSCC | 1.59e-07 | 5.42e-01 | 0.2678 |
2999 | GZMH | C46 | Human | Oral cavity | OSCC | 8.91e-04 | 1.28e-01 | 0.1673 |
2999 | GZMH | C51 | Human | Oral cavity | OSCC | 3.01e-02 | 2.38e-01 | 0.2674 |
2999 | GZMH | C07 | Human | Oral cavity | OSCC | 5.32e-03 | 3.44e-01 | 0.2491 |
2999 | GZMH | LN22 | Human | Oral cavity | OSCC | 2.14e-02 | 6.06e-01 | 0.1733 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GZMH | SNV | Missense_Mutation | novel | c.614C>A | p.Pro205His | p.P205H | P20718 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
GZMH | SNV | Missense_Mutation | c.659N>T | p.Asn220Ile | p.N220I | P20718 | protein_coding | tolerated(0.08) | benign(0.092) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
GZMH | SNV | Missense_Mutation | c.148N>T | p.Gly50Cys | p.G50C | P20718 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A12V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GZMH | SNV | Missense_Mutation | c.640G>T | p.Gly214Cys | p.G214C | P20718 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GZMH | SNV | Missense_Mutation | c.107C>T | p.Ala36Val | p.A36V | P20718 | protein_coding | deleterious(0.04) | possibly_damaging(0.794) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GZMH | SNV | Missense_Mutation | c.613N>T | p.Pro205Ser | p.P205S | P20718 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-D5-6932-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GZMH | SNV | Missense_Mutation | c.250N>T | p.Arg84Trp | p.R84W | P20718 | protein_coding | deleterious(0.04) | benign(0.057) | TCGA-DM-A1D6-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GZMH | SNV | Missense_Mutation | rs148085251 | c.373N>T | p.Arg125Trp | p.R125W | P20718 | protein_coding | deleterious(0.05) | benign(0.119) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GZMH | SNV | Missense_Mutation | novel | c.485N>C | p.Val162Ala | p.V162A | P20718 | protein_coding | tolerated(0.14) | possibly_damaging(0.73) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
GZMH | SNV | Missense_Mutation | novel | c.261N>C | p.Gln87His | p.Q87H | P20718 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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