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Gene: GPN3 |
Gene summary for GPN3 |
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Gene information | Species | Human | Gene symbol | GPN3 | Gene ID | 51184 |
Gene name | GPN-loop GTPase 3 | |
Gene Alias | ATPBD1C | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9UHW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51184 | GPN3 | LZE4T | Human | Esophagus | ESCC | 2.60e-11 | 2.55e-01 | 0.0811 |
51184 | GPN3 | LZE5T | Human | Esophagus | ESCC | 9.12e-04 | 2.55e-01 | 0.0514 |
51184 | GPN3 | LZE7T | Human | Esophagus | ESCC | 7.30e-08 | 4.82e-01 | 0.0667 |
51184 | GPN3 | LZE8T | Human | Esophagus | ESCC | 5.36e-06 | 2.73e-01 | 0.067 |
51184 | GPN3 | LZE22T | Human | Esophagus | ESCC | 3.41e-02 | 4.85e-01 | 0.068 |
51184 | GPN3 | LZE24T | Human | Esophagus | ESCC | 4.49e-25 | 5.29e-01 | 0.0596 |
51184 | GPN3 | LZE6T | Human | Esophagus | ESCC | 3.21e-05 | 3.15e-01 | 0.0845 |
51184 | GPN3 | P1T-E | Human | Esophagus | ESCC | 4.59e-09 | 5.02e-01 | 0.0875 |
51184 | GPN3 | P2T-E | Human | Esophagus | ESCC | 1.55e-63 | 1.01e+00 | 0.1177 |
51184 | GPN3 | P4T-E | Human | Esophagus | ESCC | 2.43e-32 | 7.54e-01 | 0.1323 |
51184 | GPN3 | P5T-E | Human | Esophagus | ESCC | 1.33e-27 | 6.11e-01 | 0.1327 |
51184 | GPN3 | P8T-E | Human | Esophagus | ESCC | 1.04e-29 | 5.13e-01 | 0.0889 |
51184 | GPN3 | P9T-E | Human | Esophagus | ESCC | 1.00e-12 | 3.02e-01 | 0.1131 |
51184 | GPN3 | P10T-E | Human | Esophagus | ESCC | 7.21e-29 | 5.51e-01 | 0.116 |
51184 | GPN3 | P11T-E | Human | Esophagus | ESCC | 1.38e-11 | 4.12e-01 | 0.1426 |
51184 | GPN3 | P12T-E | Human | Esophagus | ESCC | 1.02e-19 | 4.29e-01 | 0.1122 |
51184 | GPN3 | P15T-E | Human | Esophagus | ESCC | 1.04e-26 | 5.03e-01 | 0.1149 |
51184 | GPN3 | P16T-E | Human | Esophagus | ESCC | 2.20e-23 | 5.25e-01 | 0.1153 |
51184 | GPN3 | P17T-E | Human | Esophagus | ESCC | 5.97e-10 | 5.06e-01 | 0.1278 |
51184 | GPN3 | P19T-E | Human | Esophagus | ESCC | 1.74e-14 | 9.46e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPN3 | SNV | Missense_Mutation | c.59N>A | p.Cys20Tyr | p.C20Y | Q9UHW5 | protein_coding | deleterious_low_confidence(0) | unknown(0) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GPN3 | SNV | Missense_Mutation | c.686N>G | p.Phe229Cys | p.F229C | Q9UHW5 | protein_coding | deleterious(0) | possibly_damaging(0.598) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
GPN3 | SNV | Missense_Mutation | novel | c.886N>T | p.Asp296Tyr | p.D296Y | Q9UHW5 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GPN3 | SNV | Missense_Mutation | novel | c.255C>G | p.Phe85Leu | p.F85L | Q9UHW5 | protein_coding | tolerated(0.11) | benign(0.097) | TCGA-AJ-A2QM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
GPN3 | SNV | Missense_Mutation | rs368125599 | c.707N>A | p.Ser236Tyr | p.S236Y | Q9UHW5 | protein_coding | tolerated(1) | benign(0.022) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GPN3 | SNV | Missense_Mutation | c.637N>G | p.Thr213Ala | p.T213A | Q9UHW5 | protein_coding | deleterious(0) | possibly_damaging(0.846) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
GPN3 | SNV | Missense_Mutation | rs199875960 | c.181N>G | p.Thr61Ala | p.T61A | Q9UHW5 | protein_coding | tolerated(0.48) | benign(0.062) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPN3 | SNV | Missense_Mutation | novel | c.695N>T | p.Pro232Leu | p.P232L | Q9UHW5 | protein_coding | tolerated(0.07) | benign(0.142) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPN3 | SNV | Missense_Mutation | c.784N>A | p.Asp262Asn | p.D262N | Q9UHW5 | protein_coding | deleterious(0.04) | benign(0.315) | TCGA-D1-A169-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
GPN3 | SNV | Missense_Mutation | novel | c.22N>A | p.Ala8Thr | p.A8T | Q9UHW5 | protein_coding | unknown(0) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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