![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GLB1L |
Gene summary for GLB1L |
![]() |
Gene information | Species | Human | Gene symbol | GLB1L | Gene ID | 79411 |
Gene name | galactosidase beta 1 like | |
Gene Alias | GLB1L | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A140VJK0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79411 | GLB1L | HCC1_Meng | Human | Liver | HCC | 3.95e-07 | 1.01e-02 | 0.0246 |
79411 | GLB1L | HCC1 | Human | Liver | HCC | 1.74e-03 | 1.68e+00 | 0.5336 |
79411 | GLB1L | HCC2 | Human | Liver | HCC | 1.52e-06 | 2.13e+00 | 0.5341 |
79411 | GLB1L | HCC5 | Human | Liver | HCC | 1.08e-02 | 2.87e-01 | 0.4932 |
79411 | GLB1L | S016 | Human | Liver | HCC | 5.71e-03 | 1.52e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLB1L | SNV | Missense_Mutation | c.790N>A | p.Glu264Lys | p.E264K | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLB1L | SNV | Missense_Mutation | rs370083958 | c.766N>A | p.Pro256Thr | p.P256T | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AC-A2QJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
GLB1L | SNV | Missense_Mutation | c.416N>A | p.Arg139Gln | p.R139Q | Q6UWU2 | protein_coding | tolerated(0.6) | benign(0.015) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLB1L | SNV | Missense_Mutation | rs773572669 | c.1790N>A | p.Gly597Glu | p.G597E | Q6UWU2 | protein_coding | tolerated(0.36) | benign(0.031) | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
GLB1L | SNV | Missense_Mutation | c.1552N>T | p.Val518Leu | p.V518L | Q6UWU2 | protein_coding | tolerated(0.14) | benign(0.014) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GLB1L | SNV | Missense_Mutation | c.1276N>C | p.Glu426Gln | p.E426Q | Q6UWU2 | protein_coding | tolerated(0.33) | benign(0.017) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GLB1L | SNV | Missense_Mutation | novel | c.1470C>A | p.Phe490Leu | p.F490L | Q6UWU2 | protein_coding | tolerated(0.08) | benign(0.036) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GLB1L | SNV | Missense_Mutation | rs142820300 | c.962N>A | p.Arg321His | p.R321H | Q6UWU2 | protein_coding | tolerated(0.13) | benign(0.022) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
GLB1L | SNV | Missense_Mutation | rs773279693 | c.127G>T | p.Gly43Trp | p.G43W | Q6UWU2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GLB1L | SNV | Missense_Mutation | novel | c.613N>C | p.Phe205Leu | p.F205L | Q6UWU2 | protein_coding | tolerated(0.05) | benign(0.398) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |