![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FOPNL |
Gene summary for FOPNL |
![]() |
Gene information | Species | Human | Gene symbol | FOPNL | Gene ID | 123811 |
Gene name | centrosomal protein 20 | |
Gene Alias | C16orf63 | |
Cytomap | 16p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96NB1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123811 | FOPNL | LZE4T | Human | Esophagus | ESCC | 3.93e-11 | 6.98e-01 | 0.0811 |
123811 | FOPNL | LZE7T | Human | Esophagus | ESCC | 1.16e-07 | 6.61e-01 | 0.0667 |
123811 | FOPNL | LZE8T | Human | Esophagus | ESCC | 2.22e-08 | 3.08e-01 | 0.067 |
123811 | FOPNL | LZE20T | Human | Esophagus | ESCC | 4.70e-03 | 1.82e-01 | 0.0662 |
123811 | FOPNL | LZE24T | Human | Esophagus | ESCC | 1.61e-14 | 4.32e-01 | 0.0596 |
123811 | FOPNL | LZE21T | Human | Esophagus | ESCC | 8.30e-07 | 3.40e-01 | 0.0655 |
123811 | FOPNL | LZE6T | Human | Esophagus | ESCC | 2.76e-05 | 8.86e-02 | 0.0845 |
123811 | FOPNL | P2T-E | Human | Esophagus | ESCC | 1.55e-53 | 1.03e+00 | 0.1177 |
123811 | FOPNL | P4T-E | Human | Esophagus | ESCC | 1.13e-28 | 9.04e-01 | 0.1323 |
123811 | FOPNL | P5T-E | Human | Esophagus | ESCC | 7.07e-26 | 5.41e-01 | 0.1327 |
123811 | FOPNL | P8T-E | Human | Esophagus | ESCC | 8.24e-29 | 5.65e-01 | 0.0889 |
123811 | FOPNL | P9T-E | Human | Esophagus | ESCC | 7.30e-12 | 4.05e-01 | 0.1131 |
123811 | FOPNL | P10T-E | Human | Esophagus | ESCC | 1.55e-18 | 3.74e-01 | 0.116 |
123811 | FOPNL | P11T-E | Human | Esophagus | ESCC | 8.55e-10 | 6.86e-01 | 0.1426 |
123811 | FOPNL | P12T-E | Human | Esophagus | ESCC | 2.55e-50 | 1.21e+00 | 0.1122 |
123811 | FOPNL | P15T-E | Human | Esophagus | ESCC | 5.69e-44 | 1.13e+00 | 0.1149 |
123811 | FOPNL | P16T-E | Human | Esophagus | ESCC | 2.58e-50 | 1.03e+00 | 0.1153 |
123811 | FOPNL | P17T-E | Human | Esophagus | ESCC | 1.87e-06 | 3.90e-01 | 0.1278 |
123811 | FOPNL | P19T-E | Human | Esophagus | ESCC | 1.65e-02 | 9.05e-01 | 0.1662 |
123811 | FOPNL | P20T-E | Human | Esophagus | ESCC | 2.06e-42 | 1.21e+00 | 0.1124 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOPNL | SNV | Missense_Mutation | c.575T>G | p.Val192Gly | p.V192G | protein_coding | deleterious_low_confidence(0) | benign(0.287) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | ||
FOPNL | SNV | Missense_Mutation | c.142C>A | p.His48Asn | p.H48N | protein_coding | tolerated(0.43) | probably_damaging(0.999) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FOPNL | SNV | Missense_Mutation | novel | c.140C>T | p.Ser47Phe | p.S47F | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FOPNL | SNV | Missense_Mutation | c.509N>T | p.Arg170Ile | p.R170I | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.921) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
FOPNL | SNV | Missense_Mutation | novel | c.208N>T | p.Ala70Ser | p.A70S | protein_coding | tolerated(0.24) | benign(0.163) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FOPNL | SNV | Missense_Mutation | novel | c.212N>A | p.Ser71Tyr | p.S71Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FOPNL | SNV | Missense_Mutation | c.332N>G | p.Gln111Arg | p.Q111R | protein_coding | tolerated(0.16) | benign(0.149) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FOPNL | SNV | Missense_Mutation | c.509N>T | p.Arg170Ile | p.R170I | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.921) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
FOPNL | SNV | Missense_Mutation | novel | c.372N>T | p.Lys124Asn | p.K124N | protein_coding | tolerated(0.73) | benign(0.233) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
FOPNL | SNV | Missense_Mutation | rs201605942 | c.173G>A | p.Arg58Gln | p.R58Q | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |