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Gene: FAM96B |
Gene summary for FAM96B |
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Gene information | Species | Human | Gene symbol | FAM96B | Gene ID | 51647 |
Gene name | cytosolic iron-sulfur assembly component 2B | |
Gene Alias | CGI-128 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q9Y3D0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51647 | FAM96B | GSM4909281 | Human | Breast | IDC | 1.18e-04 | 2.73e-01 | 0.21 |
51647 | FAM96B | GSM4909282 | Human | Breast | IDC | 9.79e-16 | 4.63e-01 | -0.0288 |
51647 | FAM96B | GSM4909288 | Human | Breast | IDC | 1.30e-04 | 1.24e-02 | 0.0988 |
51647 | FAM96B | GSM4909291 | Human | Breast | IDC | 3.60e-03 | 2.67e-01 | 0.1753 |
51647 | FAM96B | GSM4909294 | Human | Breast | IDC | 2.18e-05 | 1.49e-01 | 0.2022 |
51647 | FAM96B | GSM4909296 | Human | Breast | IDC | 3.27e-08 | -5.85e-02 | 0.1524 |
51647 | FAM96B | GSM4909297 | Human | Breast | IDC | 1.72e-16 | -9.02e-02 | 0.1517 |
51647 | FAM96B | GSM4909301 | Human | Breast | IDC | 7.84e-10 | 2.50e-01 | 0.1577 |
51647 | FAM96B | GSM4909311 | Human | Breast | IDC | 4.08e-32 | -2.38e-01 | 0.1534 |
51647 | FAM96B | GSM4909312 | Human | Breast | IDC | 1.24e-11 | -1.14e-01 | 0.1552 |
51647 | FAM96B | GSM4909313 | Human | Breast | IDC | 1.05e-02 | -2.38e-01 | 0.0391 |
51647 | FAM96B | GSM4909318 | Human | Breast | IDC | 1.82e-04 | 3.20e-01 | 0.2031 |
51647 | FAM96B | GSM4909319 | Human | Breast | IDC | 2.19e-42 | -2.23e-01 | 0.1563 |
51647 | FAM96B | GSM4909320 | Human | Breast | IDC | 4.01e-15 | 3.57e-01 | 0.1575 |
51647 | FAM96B | GSM4909321 | Human | Breast | IDC | 1.70e-38 | 5.18e-01 | 0.1559 |
51647 | FAM96B | brca1 | Human | Breast | Precancer | 1.11e-21 | 5.43e-01 | -0.0338 |
51647 | FAM96B | brca2 | Human | Breast | Precancer | 1.42e-04 | 2.07e-01 | -0.024 |
51647 | FAM96B | brca3 | Human | Breast | Precancer | 1.82e-09 | 2.62e-01 | -0.0263 |
51647 | FAM96B | M2 | Human | Breast | IDC | 5.70e-03 | 6.72e-02 | 0.21 |
51647 | FAM96B | NCCBC11 | Human | Breast | DCIS | 3.91e-02 | -2.34e-01 | 0.1232 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM96B | SNV | Missense_Mutation | c.484C>T | p.Arg162Cys | p.R162C | Q9Y3D0 | protein_coding | tolerated_low_confidence(0.1) | benign(0.01) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
FAM96B | insertion | Frame_Shift_Ins | novel | c.167_168insATTAGCAGAGAGGAAACTG | p.Glu57LeufsTer26 | p.E57Lfs*26 | Q9Y3D0 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAM96B | SNV | Missense_Mutation | c.484N>T | p.Arg162Cys | p.R162C | Q9Y3D0 | protein_coding | tolerated_low_confidence(0.1) | benign(0.01) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM96B | SNV | Missense_Mutation | novel | c.171N>T | p.Glu57Asp | p.E57D | Q9Y3D0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FAM96B | SNV | Missense_Mutation | novel | c.70N>T | p.Gly24Trp | p.G24W | Q9Y3D0 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM96B | SNV | Missense_Mutation | novel | c.157N>T | p.Ile53Phe | p.I53F | Q9Y3D0 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-MP-A4T9-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | vinorelbine | PD |
FAM96B | SNV | Missense_Mutation | c.144N>A | p.Asp48Glu | p.D48E | Q9Y3D0 | protein_coding | tolerated(0.22) | possibly_damaging(0.498) | TCGA-J4-A67Q-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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