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Gene: FAM43A |
Gene summary for FAM43A |
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Gene information | Species | Human | Gene symbol | FAM43A | Gene ID | 131583 |
Gene name | family with sequence similarity 43 member A | |
Gene Alias | FAM43A | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N2R8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131583 | FAM43A | LZE4T | Human | Esophagus | ESCC | 5.18e-03 | 1.85e-01 | 0.0811 |
131583 | FAM43A | LZE7T | Human | Esophagus | ESCC | 5.93e-07 | 5.55e-01 | 0.0667 |
131583 | FAM43A | LZE21D1 | Human | Esophagus | HGIN | 1.40e-05 | 7.41e-01 | 0.0632 |
131583 | FAM43A | LZE24T | Human | Esophagus | ESCC | 3.25e-17 | 6.32e-01 | 0.0596 |
131583 | FAM43A | LZE21T | Human | Esophagus | ESCC | 5.46e-09 | 8.63e-01 | 0.0655 |
131583 | FAM43A | P4T-E | Human | Esophagus | ESCC | 2.07e-20 | 5.88e-01 | 0.1323 |
131583 | FAM43A | P8T-E | Human | Esophagus | ESCC | 1.56e-09 | 2.16e-01 | 0.0889 |
131583 | FAM43A | P9T-E | Human | Esophagus | ESCC | 1.78e-07 | 2.65e-01 | 0.1131 |
131583 | FAM43A | P10T-E | Human | Esophagus | ESCC | 1.38e-25 | 5.05e-01 | 0.116 |
131583 | FAM43A | P11T-E | Human | Esophagus | ESCC | 1.94e-02 | 3.12e-01 | 0.1426 |
131583 | FAM43A | P12T-E | Human | Esophagus | ESCC | 1.97e-29 | 5.65e-01 | 0.1122 |
131583 | FAM43A | P15T-E | Human | Esophagus | ESCC | 1.05e-02 | 1.15e-01 | 0.1149 |
131583 | FAM43A | P16T-E | Human | Esophagus | ESCC | 1.41e-07 | 5.81e-02 | 0.1153 |
131583 | FAM43A | P22T-E | Human | Esophagus | ESCC | 6.24e-09 | 2.77e-01 | 0.1236 |
131583 | FAM43A | P23T-E | Human | Esophagus | ESCC | 5.30e-05 | 8.92e-02 | 0.108 |
131583 | FAM43A | P26T-E | Human | Esophagus | ESCC | 1.30e-09 | 2.40e-01 | 0.1276 |
131583 | FAM43A | P27T-E | Human | Esophagus | ESCC | 2.00e-17 | 3.57e-01 | 0.1055 |
131583 | FAM43A | P28T-E | Human | Esophagus | ESCC | 1.50e-21 | 4.83e-01 | 0.1149 |
131583 | FAM43A | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 7.46e-01 | 0.137 |
131583 | FAM43A | P32T-E | Human | Esophagus | ESCC | 4.03e-04 | 2.17e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM43A | SNV | Missense_Mutation | rs753788243 | c.297N>C | p.Lys99Asn | p.K99N | Q8N2R8 | protein_coding | tolerated(0.2) | probably_damaging(0.93) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
FAM43A | SNV | Missense_Mutation | novel | c.412C>G | p.His138Asp | p.H138D | Q8N2R8 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
FAM43A | SNV | Missense_Mutation | c.587N>C | p.Leu196Pro | p.L196P | Q8N2R8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | c.451N>G | p.Lys151Glu | p.K151E | Q8N2R8 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | c.910N>A | p.Val304Ile | p.V304I | Q8N2R8 | protein_coding | tolerated_low_confidence(0.1) | benign(0.015) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | c.808N>A | p.Glu270Lys | p.E270K | Q8N2R8 | protein_coding | deleterious(0.01) | benign(0.15) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | novel | c.317G>A | p.Gly106Asp | p.G106D | Q8N2R8 | protein_coding | tolerated(0.19) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FAM43A | SNV | Missense_Mutation | c.125N>T | p.Cys42Phe | p.C42F | Q8N2R8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | c.8C>T | p.Pro3Leu | p.P3L | Q8N2R8 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-55-1594-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FAM43A | SNV | Missense_Mutation | c.298A>T | p.Ser100Cys | p.S100C | Q8N2R8 | protein_coding | tolerated(0.12) | probably_damaging(0.998) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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