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Gene: FAM109B |
Gene summary for FAM109B |
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Gene information | Species | Human | Gene symbol | FAM109B | Gene ID | 150368 |
Gene name | PH domain containing endocytic trafficking adaptor 2 | |
Gene Alias | FAM109B | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001881 | UniProtAcc | Q6ICB4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
150368 | FAM109B | P2T-E | Human | Esophagus | ESCC | 1.09e-08 | 1.01e-01 | 0.1177 |
150368 | FAM109B | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 1.67e-01 | 0.1323 |
150368 | FAM109B | P5T-E | Human | Esophagus | ESCC | 2.62e-09 | 1.59e-01 | 0.1327 |
150368 | FAM109B | P9T-E | Human | Esophagus | ESCC | 8.59e-07 | 1.86e-01 | 0.1131 |
150368 | FAM109B | P10T-E | Human | Esophagus | ESCC | 3.54e-11 | 1.75e-01 | 0.116 |
150368 | FAM109B | P11T-E | Human | Esophagus | ESCC | 6.74e-09 | 2.64e-01 | 0.1426 |
150368 | FAM109B | P12T-E | Human | Esophagus | ESCC | 4.51e-12 | 2.88e-01 | 0.1122 |
150368 | FAM109B | P16T-E | Human | Esophagus | ESCC | 1.43e-13 | 2.68e-01 | 0.1153 |
150368 | FAM109B | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.58e-01 | 0.1278 |
150368 | FAM109B | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 2.66e-01 | 0.1662 |
150368 | FAM109B | P20T-E | Human | Esophagus | ESCC | 4.38e-08 | 1.92e-01 | 0.1124 |
150368 | FAM109B | P21T-E | Human | Esophagus | ESCC | 1.18e-03 | 7.67e-02 | 0.1617 |
150368 | FAM109B | P23T-E | Human | Esophagus | ESCC | 5.52e-07 | 1.62e-01 | 0.108 |
150368 | FAM109B | P24T-E | Human | Esophagus | ESCC | 7.24e-08 | 1.79e-01 | 0.1287 |
150368 | FAM109B | P27T-E | Human | Esophagus | ESCC | 1.04e-07 | 1.20e-01 | 0.1055 |
150368 | FAM109B | P28T-E | Human | Esophagus | ESCC | 2.22e-11 | 1.39e-01 | 0.1149 |
150368 | FAM109B | P30T-E | Human | Esophagus | ESCC | 3.85e-06 | 1.99e-01 | 0.137 |
150368 | FAM109B | P31T-E | Human | Esophagus | ESCC | 3.09e-12 | 1.11e-01 | 0.1251 |
150368 | FAM109B | P37T-E | Human | Esophagus | ESCC | 8.12e-03 | 9.69e-02 | 0.1371 |
150368 | FAM109B | P39T-E | Human | Esophagus | ESCC | 6.46e-10 | 1.06e-01 | 0.0894 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM109B | SNV | Missense_Mutation | novel | c.433N>G | p.Gln145Glu | p.Q145E | Q6ICB4 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM109B | SNV | Missense_Mutation | novel | c.182G>T | p.Arg61Leu | p.R61L | Q6ICB4 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
FAM109B | SNV | Missense_Mutation | c.274N>C | p.Asp92His | p.D92H | Q6ICB4 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM109B | insertion | In_Frame_Ins | novel | c.608_609insACT | p.Gln203_Gly204insLeu | p.Q203_G204insL | Q6ICB4 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
FAM109B | SNV | Missense_Mutation | c.146G>A | p.Gly49Asp | p.G49D | Q6ICB4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM109B | SNV | Missense_Mutation | rs779209620 | c.715C>T | p.Arg239Trp | p.R239W | Q6ICB4 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM109B | SNV | Missense_Mutation | c.440G>A | p.Arg147His | p.R147H | Q6ICB4 | protein_coding | tolerated(0.26) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM109B | SNV | Missense_Mutation | rs146670018 | c.416N>A | p.Arg139His | p.R139H | Q6ICB4 | protein_coding | tolerated(0.07) | benign(0.021) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
FAM109B | SNV | Missense_Mutation | novel | c.566G>A | p.Gly189Asp | p.G189D | Q6ICB4 | protein_coding | tolerated(0.18) | possibly_damaging(0.648) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM109B | SNV | Missense_Mutation | novel | c.754N>C | p.Lys252Gln | p.K252Q | Q6ICB4 | protein_coding | tolerated_low_confidence(0.36) | benign(0.005) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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