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Gene: DEK |
Gene summary for DEK |
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Gene information | Species | Human | Gene symbol | DEK | Gene ID | 7913 |
Gene name | DEK proto-oncogene | |
Gene Alias | D6S231E | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P35659 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7913 | DEK | GSM4909281 | Human | Breast | IDC | 1.38e-62 | 8.81e-01 | 0.21 |
7913 | DEK | GSM4909282 | Human | Breast | IDC | 2.90e-71 | 9.17e-01 | -0.0288 |
7913 | DEK | GSM4909285 | Human | Breast | IDC | 6.44e-22 | 5.03e-01 | 0.21 |
7913 | DEK | GSM4909286 | Human | Breast | IDC | 8.45e-17 | 4.33e-01 | 0.1081 |
7913 | DEK | GSM4909287 | Human | Breast | IDC | 7.86e-08 | 3.00e-01 | 0.2057 |
7913 | DEK | GSM4909288 | Human | Breast | IDC | 2.36e-11 | 2.97e-01 | 0.0988 |
7913 | DEK | GSM4909289 | Human | Breast | IDC | 2.55e-22 | 8.93e-01 | 0.1064 |
7913 | DEK | GSM4909293 | Human | Breast | IDC | 2.38e-05 | 2.17e-01 | 0.1581 |
7913 | DEK | GSM4909294 | Human | Breast | IDC | 2.76e-07 | -3.76e-01 | 0.2022 |
7913 | DEK | GSM4909296 | Human | Breast | IDC | 7.10e-11 | -3.20e-01 | 0.1524 |
7913 | DEK | GSM4909297 | Human | Breast | IDC | 1.91e-13 | -2.51e-01 | 0.1517 |
7913 | DEK | GSM4909298 | Human | Breast | IDC | 9.09e-04 | 2.08e-01 | 0.1551 |
7913 | DEK | GSM4909302 | Human | Breast | IDC | 1.62e-02 | -2.79e-01 | 0.1545 |
7913 | DEK | GSM4909311 | Human | Breast | IDC | 1.46e-31 | -3.46e-01 | 0.1534 |
7913 | DEK | GSM4909312 | Human | Breast | IDC | 1.83e-15 | 3.17e-02 | 0.1552 |
7913 | DEK | GSM4909313 | Human | Breast | IDC | 2.61e-02 | -1.37e-01 | 0.0391 |
7913 | DEK | GSM4909316 | Human | Breast | IDC | 3.23e-02 | -2.89e-01 | 0.21 |
7913 | DEK | GSM4909319 | Human | Breast | IDC | 6.96e-40 | -3.08e-01 | 0.1563 |
7913 | DEK | GSM4909320 | Human | Breast | IDC | 3.41e-08 | -2.13e-01 | 0.1575 |
7913 | DEK | GSM4909321 | Human | Breast | IDC | 4.35e-18 | -2.95e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00190799 | Breast | Precancer | viral genome replication | 22/1080 | 131/18723 | 5.63e-06 | 1.66e-04 | 22 |
GO:20010208 | Breast | Precancer | regulation of response to DNA damage stimulus | 24/1080 | 219/18723 | 1.93e-03 | 1.87e-02 | 24 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
GO:200102013 | Breast | IDC | regulation of response to DNA damage stimulus | 30/1434 | 219/18723 | 1.36e-03 | 1.40e-02 | 30 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:001907923 | Breast | DCIS | viral genome replication | 30/1390 | 131/18723 | 2.12e-08 | 1.45e-06 | 30 |
GO:200102023 | Breast | DCIS | regulation of response to DNA damage stimulus | 30/1390 | 219/18723 | 8.32e-04 | 9.47e-03 | 30 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0006282 | Colorectum | AD | regulation of DNA repair | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DEK | SNV | Missense_Mutation | c.904G>A | p.Glu302Lys | p.E302K | P35659 | protein_coding | tolerated(0.26) | benign(0.112) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
DEK | SNV | Missense_Mutation | c.700N>A | p.Glu234Lys | p.E234K | P35659 | protein_coding | tolerated(0.08) | probably_damaging(0.98) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DEK | insertion | Nonsense_Mutation | novel | c.949_950insTTCTGCTTCTTTAAACTAACATAAACTAAGGATACATCAAT | p.Lys317IlefsTer5 | p.K317Ifs*5 | P35659 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DEK | SNV | Missense_Mutation | c.904G>C | p.Glu302Gln | p.E302Q | P35659 | protein_coding | tolerated(0.16) | benign(0.249) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
DEK | SNV | Missense_Mutation | novel | c.1081N>A | p.Glu361Lys | p.E361K | P35659 | protein_coding | tolerated(0.29) | possibly_damaging(0.83) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DEK | SNV | Missense_Mutation | c.476G>A | p.Ser159Asn | p.S159N | P35659 | protein_coding | tolerated(0.43) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DEK | SNV | Missense_Mutation | novel | c.524N>G | p.Leu175Arg | p.L175R | P35659 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DEK | deletion | Frame_Shift_Del | novel | c.1113delN | p.Glu372SerfsTer2 | p.E372Sfs*2 | P35659 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
DEK | deletion | Frame_Shift_Del | c.31delG | p.Glu11ArgfsTer53 | p.E11Rfs*53 | P35659 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DEK | deletion | Frame_Shift_Del | c.773delN | p.Lys258ArgfsTer20 | p.K258Rfs*20 | P35659 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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