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Gene: CMAS |
Gene summary for CMAS |
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Gene information | Species | Human | Gene symbol | CMAS | Gene ID | 55907 |
Gene name | cytidine monophosphate N-acetylneuraminic acid synthetase | |
Gene Alias | CSS | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006040 | UniProtAcc | Q8NFW8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55907 | CMAS | HTA11_78_2000001011 | Human | Colorectum | AD | 2.40e-02 | 4.86e-01 | -0.1088 |
55907 | CMAS | HTA11_347_2000001011 | Human | Colorectum | AD | 1.08e-17 | 8.15e-01 | -0.1954 |
55907 | CMAS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.12e-13 | 7.25e-01 | 0.294 |
55907 | CMAS | A015-C-203 | Human | Colorectum | FAP | 1.58e-04 | -1.60e-01 | -0.1294 |
55907 | CMAS | A015-C-204 | Human | Colorectum | FAP | 9.76e-04 | -2.17e-01 | -0.0228 |
55907 | CMAS | A002-C-201 | Human | Colorectum | FAP | 6.60e-06 | -1.42e-01 | 0.0324 |
55907 | CMAS | A001-C-119 | Human | Colorectum | FAP | 3.74e-05 | -3.01e-01 | -0.1557 |
55907 | CMAS | A001-C-108 | Human | Colorectum | FAP | 4.45e-02 | -1.54e-01 | -0.0272 |
55907 | CMAS | A002-C-205 | Human | Colorectum | FAP | 8.27e-12 | -2.93e-01 | -0.1236 |
55907 | CMAS | A015-C-005 | Human | Colorectum | FAP | 1.14e-04 | -2.26e-01 | -0.0336 |
55907 | CMAS | A015-C-006 | Human | Colorectum | FAP | 1.93e-04 | -1.63e-01 | -0.0994 |
55907 | CMAS | A015-C-106 | Human | Colorectum | FAP | 2.29e-02 | -1.54e-01 | -0.0511 |
55907 | CMAS | A002-C-114 | Human | Colorectum | FAP | 9.69e-07 | -1.34e-01 | -0.1561 |
55907 | CMAS | A015-C-104 | Human | Colorectum | FAP | 9.97e-07 | -2.30e-01 | -0.1899 |
55907 | CMAS | A001-C-014 | Human | Colorectum | FAP | 2.06e-02 | -1.80e-01 | 0.0135 |
55907 | CMAS | A002-C-016 | Human | Colorectum | FAP | 2.71e-05 | -1.66e-01 | 0.0521 |
55907 | CMAS | A015-C-002 | Human | Colorectum | FAP | 2.23e-04 | -2.14e-01 | -0.0763 |
55907 | CMAS | A001-C-203 | Human | Colorectum | FAP | 4.75e-02 | -1.45e-01 | -0.0481 |
55907 | CMAS | A002-C-116 | Human | Colorectum | FAP | 2.65e-06 | -1.68e-01 | -0.0452 |
55907 | CMAS | A014-C-008 | Human | Colorectum | FAP | 5.93e-05 | -2.34e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006040 | Oral cavity | OSCC | amino sugar metabolic process | 24/7305 | 42/18723 | 1.30e-02 | 4.34e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01250 | Colorectum | FAP | Biosynthesis of nucleotide sugars | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa012501 | Colorectum | FAP | Biosynthesis of nucleotide sugars | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa012502 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa012503 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa00520 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
hsa005201 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMAS | SNV | Missense_Mutation | novel | c.751N>C | p.Asp251His | p.D251H | Q8NFW8 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CMAS | SNV | Missense_Mutation | novel | c.808N>A | p.Glu270Lys | p.E270K | Q8NFW8 | protein_coding | tolerated(0.23) | benign(0.304) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMAS | SNV | Missense_Mutation | rs757760901 | c.485N>A | p.Arg162Gln | p.R162Q | Q8NFW8 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CMAS | SNV | Missense_Mutation | novel | c.1043N>T | p.Ser348Leu | p.S348L | Q8NFW8 | protein_coding | tolerated(0.24) | benign(0) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
CMAS | insertion | In_Frame_Ins | novel | c.132_133insACACTCTTTCACAGCACAAATCACACTCTA | p.His44_Leu45insThrLeuPheHisSerThrAsnHisThrLeu | p.H44_L45insTLFHSTNHTL | Q8NFW8 | protein_coding | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CMAS | deletion | Frame_Shift_Del | novel | c.958delN | p.Glu320ArgfsTer2 | p.E320Rfs*2 | Q8NFW8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CMAS | SNV | Missense_Mutation | c.760T>C | p.Trp254Arg | p.W254R | Q8NFW8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CMAS | SNV | Missense_Mutation | c.353N>T | p.Asp118Val | p.D118V | Q8NFW8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CMAS | SNV | Missense_Mutation | rs753560501 | c.329N>A | p.Arg110Gln | p.R110Q | Q8NFW8 | protein_coding | tolerated(0.06) | benign(0.318) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CMAS | SNV | Missense_Mutation | c.828N>C | p.Lys276Asn | p.K276N | Q8NFW8 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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