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Gene: CLPTM1L |
Gene summary for CLPTM1L |
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Gene information | Species | Human | Gene symbol | CLPTM1L | Gene ID | 81037 |
Gene name | CLPTM1 like | |
Gene Alias | CRR9 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q96KA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81037 | CLPTM1L | HTA11_347_2000001011 | Human | Colorectum | AD | 7.01e-05 | 2.82e-01 | -0.1954 |
81037 | CLPTM1L | HTA11_696_2000001011 | Human | Colorectum | AD | 1.84e-07 | 3.35e-01 | -0.1464 |
81037 | CLPTM1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.57e-10 | 4.65e-01 | -0.059 |
81037 | CLPTM1L | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.39e-03 | 2.79e-01 | -0.0179 |
81037 | CLPTM1L | HTA11_866_3004761011 | Human | Colorectum | AD | 4.53e-04 | 3.03e-01 | 0.096 |
81037 | CLPTM1L | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.22e-04 | 3.57e-01 | 0.0674 |
81037 | CLPTM1L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.83e-08 | 4.08e-01 | 0.294 |
81037 | CLPTM1L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.43e-18 | 7.11e-01 | 0.3859 |
81037 | CLPTM1L | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.81e-04 | 5.18e-01 | 0.2585 |
81037 | CLPTM1L | A002-C-116 | Human | Colorectum | FAP | 9.45e-03 | -5.34e-02 | -0.0452 |
81037 | CLPTM1L | LZE2T | Human | Esophagus | ESCC | 5.92e-06 | 6.23e-01 | 0.082 |
81037 | CLPTM1L | LZE5T | Human | Esophagus | ESCC | 1.73e-05 | 3.20e-01 | 0.0514 |
81037 | CLPTM1L | LZE7T | Human | Esophagus | ESCC | 9.58e-03 | 2.67e-01 | 0.0667 |
81037 | CLPTM1L | LZE8T | Human | Esophagus | ESCC | 8.38e-03 | 1.32e-01 | 0.067 |
81037 | CLPTM1L | LZE20T | Human | Esophagus | ESCC | 1.31e-08 | 2.24e-01 | 0.0662 |
81037 | CLPTM1L | LZE22T | Human | Esophagus | ESCC | 1.44e-04 | 2.21e-01 | 0.068 |
81037 | CLPTM1L | LZE24T | Human | Esophagus | ESCC | 8.63e-09 | 1.10e-01 | 0.0596 |
81037 | CLPTM1L | P1T-E | Human | Esophagus | ESCC | 4.74e-09 | 2.21e-01 | 0.0875 |
81037 | CLPTM1L | P2T-E | Human | Esophagus | ESCC | 9.71e-11 | 1.52e-01 | 0.1177 |
81037 | CLPTM1L | P4T-E | Human | Esophagus | ESCC | 1.52e-16 | 5.15e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLPTM1L | SNV | Missense_Mutation | novel | c.1195N>G | p.Gln399Glu | p.Q399E | Q96KA5 | protein_coding | tolerated(0.56) | benign(0.021) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
CLPTM1L | SNV | Missense_Mutation | c.1498N>A | p.Asp500Asn | p.D500N | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CLPTM1L | SNV | Missense_Mutation | c.1438G>A | p.Asp480Asn | p.D480N | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CLPTM1L | SNV | Missense_Mutation | c.753N>G | p.Phe251Leu | p.F251L | Q96KA5 | protein_coding | tolerated(1) | benign(0.031) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
CLPTM1L | insertion | Frame_Shift_Ins | novel | c.1081-1_1081insGGGTG | p.Leu361GlyfsTer6 | p.L361Gfs*6 | Q96KA5 | protein_coding | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
CLPTM1L | deletion | Frame_Shift_Del | novel | c.1003delN | p.Val335SerfsTer30 | p.V335Sfs*30 | Q96KA5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CLPTM1L | SNV | Missense_Mutation | c.753N>G | p.Phe251Leu | p.F251L | Q96KA5 | protein_coding | tolerated(1) | benign(0.031) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CLPTM1L | SNV | Missense_Mutation | rs745665981 | c.1477C>T | p.Arg493Trp | p.R493W | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CLPTM1L | SNV | Missense_Mutation | c.1498G>A | p.Asp500Asn | p.D500N | Q96KA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CLPTM1L | deletion | Frame_Shift_Del | c.616delA | p.Thr206ProfsTer17 | p.T206Pfs*17 | Q96KA5 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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