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Gene: CFAP69 |
Gene summary for CFAP69 |
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Gene information | Species | Human | Gene symbol | CFAP69 | Gene ID | 79846 |
Gene name | cilia and flagella associated protein 69 | |
Gene Alias | C7orf63 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A5D8W1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79846 | CFAP69 | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.36e-01 | 0.2065 |
79846 | CFAP69 | PTC06 | Human | Thyroid | PTC | 3.49e-02 | 7.84e-02 | 0.2057 |
79846 | CFAP69 | PTC07 | Human | Thyroid | PTC | 1.11e-03 | 6.38e-02 | 0.2044 |
79846 | CFAP69 | ATC13 | Human | Thyroid | ATC | 2.57e-60 | 1.12e+00 | 0.34 |
79846 | CFAP69 | ATC5 | Human | Thyroid | ATC | 4.74e-72 | 1.19e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:003288613 | Thyroid | ATC | regulation of microtubule-based process | 114/6293 | 240/18723 | 5.17e-06 | 5.59e-05 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP69 | SNV | Missense_Mutation | c.216G>C | p.Lys72Asn | p.K72N | A5D8W1 | protein_coding | tolerated(0.09) | benign(0.168) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
CFAP69 | SNV | Missense_Mutation | c.1510N>A | p.Glu504Lys | p.E504K | A5D8W1 | protein_coding | deleterious(0) | benign(0.167) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP69 | SNV | Missense_Mutation | c.502N>G | p.His168Asp | p.H168D | A5D8W1 | protein_coding | tolerated(0.44) | possibly_damaging(0.51) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CFAP69 | SNV | Missense_Mutation | novel | c.2148G>T | p.Glu716Asp | p.E716D | A5D8W1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP69 | SNV | Missense_Mutation | c.1082A>T | p.Tyr361Phe | p.Y361F | A5D8W1 | protein_coding | tolerated(0.15) | possibly_damaging(0.447) | TCGA-AR-A2LR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP69 | SNV | Missense_Mutation | c.1879N>G | p.Asn627Asp | p.N627D | A5D8W1 | protein_coding | deleterious(0.03) | possibly_damaging(0.864) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CFAP69 | SNV | Missense_Mutation | c.2666N>A | p.Gly889Asp | p.G889D | A5D8W1 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD | |
CFAP69 | SNV | Missense_Mutation | rs777182713 | c.1804N>A | p.Glu602Lys | p.E602K | A5D8W1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CFAP69 | insertion | Frame_Shift_Ins | novel | c.838_839insAAGAAAAACTTTTTAAAAGTATA | p.Leu280GlnfsTer18 | p.L280Qfs*18 | A5D8W1 | protein_coding | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP69 | insertion | Frame_Shift_Ins | novel | c.2061dupA | p.Pro688ThrfsTer5 | p.P688Tfs*5 | A5D8W1 | protein_coding | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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