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Gene: CEP95 |
Gene summary for CEP95 |
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Gene information | Species | Human | Gene symbol | CEP95 | Gene ID | 90799 |
Gene name | centrosomal protein 95 | |
Gene Alias | CCDC45 | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000922 | UniProtAcc | Q96GE4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90799 | CEP95 | LZE2T | Human | Esophagus | ESCC | 1.33e-02 | 4.40e-01 | 0.082 |
90799 | CEP95 | LZE4T | Human | Esophagus | ESCC | 7.48e-14 | 4.64e-01 | 0.0811 |
90799 | CEP95 | LZE7T | Human | Esophagus | ESCC | 1.12e-12 | 5.17e-01 | 0.0667 |
90799 | CEP95 | LZE20T | Human | Esophagus | ESCC | 5.76e-04 | 1.66e-01 | 0.0662 |
90799 | CEP95 | LZE21D1 | Human | Esophagus | HGIN | 3.90e-02 | 2.88e-01 | 0.0632 |
90799 | CEP95 | LZE22T | Human | Esophagus | ESCC | 5.99e-05 | 2.34e-01 | 0.068 |
90799 | CEP95 | LZE24T | Human | Esophagus | ESCC | 2.98e-22 | 5.95e-01 | 0.0596 |
90799 | CEP95 | LZE21T | Human | Esophagus | ESCC | 2.15e-08 | 4.54e-01 | 0.0655 |
90799 | CEP95 | LZE6T | Human | Esophagus | ESCC | 1.90e-02 | 1.29e-01 | 0.0845 |
90799 | CEP95 | P1T-E | Human | Esophagus | ESCC | 1.29e-39 | 1.98e+00 | 0.0875 |
90799 | CEP95 | P2T-E | Human | Esophagus | ESCC | 6.96e-39 | 6.52e-01 | 0.1177 |
90799 | CEP95 | P4T-E | Human | Esophagus | ESCC | 3.50e-14 | 4.01e-01 | 0.1323 |
90799 | CEP95 | P5T-E | Human | Esophagus | ESCC | 5.82e-10 | 2.07e-01 | 0.1327 |
90799 | CEP95 | P8T-E | Human | Esophagus | ESCC | 1.03e-26 | 4.42e-01 | 0.0889 |
90799 | CEP95 | P9T-E | Human | Esophagus | ESCC | 4.67e-13 | 2.76e-01 | 0.1131 |
90799 | CEP95 | P10T-E | Human | Esophagus | ESCC | 1.86e-30 | 5.33e-01 | 0.116 |
90799 | CEP95 | P11T-E | Human | Esophagus | ESCC | 5.30e-11 | 6.62e-01 | 0.1426 |
90799 | CEP95 | P12T-E | Human | Esophagus | ESCC | 4.44e-29 | 5.61e-01 | 0.1122 |
90799 | CEP95 | P15T-E | Human | Esophagus | ESCC | 5.57e-28 | 6.82e-01 | 0.1149 |
90799 | CEP95 | P16T-E | Human | Esophagus | ESCC | 1.06e-22 | 4.55e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP95 | SNV | Missense_Mutation | novel | c.866N>T | p.Ser289Phe | p.S289F | Q96GE4 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CEP95 | SNV | Missense_Mutation | c.151N>A | p.Leu51Ile | p.L51I | Q96GE4 | protein_coding | deleterious(0.02) | benign(0.169) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
CEP95 | SNV | Missense_Mutation | c.644C>G | p.Ser215Cys | p.S215C | Q96GE4 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
CEP95 | SNV | Missense_Mutation | c.282N>T | p.Lys94Asn | p.K94N | Q96GE4 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CEP95 | SNV | Missense_Mutation | c.2274G>C | p.Glu758Asp | p.E758D | Q96GE4 | protein_coding | deleterious(0.01) | benign(0.439) | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP95 | SNV | Missense_Mutation | c.452N>T | p.Trp151Leu | p.W151L | Q96GE4 | protein_coding | tolerated(0.94) | benign(0.172) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CEP95 | SNV | Missense_Mutation | novel | c.581N>T | p.Arg194Ile | p.R194I | Q96GE4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP95 | SNV | Missense_Mutation | novel | c.1996G>A | p.Ala666Thr | p.A666T | Q96GE4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
CEP95 | SNV | Missense_Mutation | novel | c.395N>T | p.Ser132Phe | p.S132F | Q96GE4 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
CEP95 | SNV | Missense_Mutation | novel | c.1046N>T | p.Ser349Leu | p.S349L | Q96GE4 | protein_coding | tolerated(0.12) | benign(0.009) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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