![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CEP57 |
Gene summary for CEP57 |
![]() |
Gene information | Species | Human | Gene symbol | CEP57 | Gene ID | 9702 |
Gene name | centrosomal protein 57 | |
Gene Alias | MVA2 | |
Cytomap | 11q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86XR8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9702 | CEP57 | LZE2T | Human | Esophagus | ESCC | 5.26e-05 | 8.69e-01 | 0.082 |
9702 | CEP57 | LZE4T | Human | Esophagus | ESCC | 1.22e-10 | 3.19e-01 | 0.0811 |
9702 | CEP57 | LZE5T | Human | Esophagus | ESCC | 6.99e-03 | 2.66e-01 | 0.0514 |
9702 | CEP57 | LZE7T | Human | Esophagus | ESCC | 3.47e-13 | 7.02e-01 | 0.0667 |
9702 | CEP57 | LZE8T | Human | Esophagus | ESCC | 8.85e-04 | 2.30e-01 | 0.067 |
9702 | CEP57 | LZE20T | Human | Esophagus | ESCC | 8.88e-08 | 2.45e-01 | 0.0662 |
9702 | CEP57 | LZE24T | Human | Esophagus | ESCC | 2.75e-28 | 8.27e-01 | 0.0596 |
9702 | CEP57 | LZE21T | Human | Esophagus | ESCC | 6.28e-07 | 3.12e-01 | 0.0655 |
9702 | CEP57 | LZE6T | Human | Esophagus | ESCC | 1.45e-02 | 2.72e-01 | 0.0845 |
9702 | CEP57 | P1T-E | Human | Esophagus | ESCC | 4.57e-08 | 5.87e-01 | 0.0875 |
9702 | CEP57 | P2T-E | Human | Esophagus | ESCC | 5.68e-38 | 6.74e-01 | 0.1177 |
9702 | CEP57 | P4T-E | Human | Esophagus | ESCC | 4.38e-51 | 1.22e+00 | 0.1323 |
9702 | CEP57 | P5T-E | Human | Esophagus | ESCC | 1.32e-17 | 4.34e-01 | 0.1327 |
9702 | CEP57 | P8T-E | Human | Esophagus | ESCC | 7.21e-12 | 2.76e-01 | 0.0889 |
9702 | CEP57 | P9T-E | Human | Esophagus | ESCC | 5.70e-17 | 4.09e-01 | 0.1131 |
9702 | CEP57 | P10T-E | Human | Esophagus | ESCC | 9.50e-36 | 7.25e-01 | 0.116 |
9702 | CEP57 | P11T-E | Human | Esophagus | ESCC | 1.86e-11 | 7.21e-01 | 0.1426 |
9702 | CEP57 | P12T-E | Human | Esophagus | ESCC | 9.69e-52 | 9.50e-01 | 0.1122 |
9702 | CEP57 | P15T-E | Human | Esophagus | ESCC | 7.81e-13 | 3.70e-01 | 0.1149 |
9702 | CEP57 | P16T-E | Human | Esophagus | ESCC | 6.72e-54 | 9.70e-01 | 0.1153 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:0051259 | Oral cavity | OSCC | protein complex oligomerization | 121/7305 | 238/18723 | 1.29e-04 | 9.21e-04 | 121 |
GO:00512591 | Oral cavity | LP | protein complex oligomerization | 85/4623 | 238/18723 | 8.81e-05 | 1.11e-03 | 85 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP57 | SNV | Missense_Mutation | c.692N>G | p.Ala231Gly | p.A231G | Q86XR8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CEP57 | SNV | Missense_Mutation | c.256N>C | p.Glu86Gln | p.E86Q | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
CEP57 | insertion | Nonsense_Mutation | novel | c.237_238insTGAGTTAATGGGTGCAGCACAGCAACATGGCACATGT | p.Ile80Ter | p.I80* | Q86XR8 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
CEP57 | insertion | Nonsense_Mutation | novel | c.190_191insTACTTAAATGATACAAT | p.Ser64IlefsTer4 | p.S64Ifs*4 | Q86XR8 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
CEP57 | insertion | Frame_Shift_Ins | novel | c.937_938insT | p.Met314AsnfsTer6 | p.M314Nfs*6 | Q86XR8 | protein_coding | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | ||
CEP57 | deletion | Frame_Shift_Del | novel | c.1238delA | p.Asn413ThrfsTer3 | p.N413Tfs*3 | Q86XR8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CEP57 | SNV | Missense_Mutation | novel | c.574N>A | p.Leu192Ile | p.L192I | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CEP57 | SNV | Missense_Mutation | novel | c.217N>T | p.Leu73Phe | p.L73F | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
CEP57 | SNV | Missense_Mutation | rs771847891 | c.293C>G | p.Ser98Cys | p.S98C | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CEP57 | SNV | Missense_Mutation | c.1494N>C | p.Trp498Cys | p.W498C | Q86XR8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |