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Gene: CENPA |
Gene summary for CENPA |
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Gene information | Species | Human | Gene symbol | CENPA | Gene ID | 1058 |
Gene name | centromere protein A | |
Gene Alias | CENP-A | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0000132 | UniProtAcc | P49450 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1058 | CENPA | P2T-E | Human | Esophagus | ESCC | 4.30e-10 | 7.63e-01 | 0.1177 |
1058 | CENPA | P4T-E | Human | Esophagus | ESCC | 2.11e-11 | 6.63e-01 | 0.1323 |
1058 | CENPA | P5T-E | Human | Esophagus | ESCC | 9.67e-18 | 4.51e-01 | 0.1327 |
1058 | CENPA | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 2.59e-01 | 0.1131 |
1058 | CENPA | P10T-E | Human | Esophagus | ESCC | 9.53e-09 | 5.27e-01 | 0.116 |
1058 | CENPA | P15T-E | Human | Esophagus | ESCC | 1.35e-04 | 2.68e-01 | 0.1149 |
1058 | CENPA | P16T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.38e-01 | 0.1153 |
1058 | CENPA | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 3.00e-01 | 0.1278 |
1058 | CENPA | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 2.74e-01 | 0.1124 |
1058 | CENPA | P21T-E | Human | Esophagus | ESCC | 9.02e-11 | 5.05e-01 | 0.1617 |
1058 | CENPA | P22T-E | Human | Esophagus | ESCC | 4.31e-06 | 3.72e-01 | 0.1236 |
1058 | CENPA | P24T-E | Human | Esophagus | ESCC | 4.16e-22 | 7.20e-01 | 0.1287 |
1058 | CENPA | P26T-E | Human | Esophagus | ESCC | 4.31e-06 | 3.07e-01 | 0.1276 |
1058 | CENPA | P28T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.96e-01 | 0.1149 |
1058 | CENPA | P30T-E | Human | Esophagus | ESCC | 1.02e-02 | 2.55e-01 | 0.137 |
1058 | CENPA | P31T-E | Human | Esophagus | ESCC | 9.56e-08 | 3.83e-01 | 0.1251 |
1058 | CENPA | P32T-E | Human | Esophagus | ESCC | 4.12e-11 | 3.88e-01 | 0.1666 |
1058 | CENPA | P36T-E | Human | Esophagus | ESCC | 2.11e-03 | 3.11e-01 | 0.1187 |
1058 | CENPA | P37T-E | Human | Esophagus | ESCC | 1.22e-13 | 4.94e-01 | 0.1371 |
1058 | CENPA | P38T-E | Human | Esophagus | ESCC | 2.58e-10 | 6.89e-01 | 0.127 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:003450211 | Esophagus | ESCC | protein localization to chromosome | 70/8552 | 92/18723 | 2.54e-09 | 5.64e-08 | 70 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:003001018 | Esophagus | ESCC | establishment of cell polarity | 96/8552 | 143/18723 | 1.69e-07 | 2.67e-06 | 96 |
GO:00513831 | Esophagus | ESCC | kinetochore organization | 21/8552 | 23/18723 | 5.69e-06 | 5.90e-05 | 21 |
GO:00345081 | Esophagus | ESCC | centromere complex assembly | 25/8552 | 30/18723 | 2.45e-05 | 2.09e-04 | 25 |
GO:00513821 | Esophagus | ESCC | kinetochore assembly | 16/8552 | 18/18723 | 1.78e-04 | 1.15e-03 | 16 |
GO:0000132 | Esophagus | ESCC | establishment of mitotic spindle orientation | 23/8552 | 30/18723 | 5.47e-04 | 3.00e-03 | 23 |
GO:00400011 | Esophagus | ESCC | establishment of mitotic spindle localization | 26/8552 | 35/18723 | 5.57e-04 | 3.04e-03 | 26 |
GO:00512941 | Esophagus | ESCC | establishment of spindle orientation | 27/8552 | 37/18723 | 7.00e-04 | 3.66e-03 | 27 |
GO:00516533 | Esophagus | ESCC | spindle localization | 37/8552 | 56/18723 | 1.65e-03 | 7.65e-03 | 37 |
GO:0051293 | Esophagus | ESCC | establishment of spindle localization | 33/8552 | 51/18723 | 4.77e-03 | 1.85e-02 | 33 |
GO:00714591 | Esophagus | ESCC | protein localization to chromosome, centromeric region | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:19028506 | Oral cavity | OSCC | microtubule cytoskeleton organization involved in mitosis | 99/7305 | 147/18723 | 2.94e-12 | 1.18e-10 | 99 |
GO:000716318 | Oral cavity | OSCC | establishment or maintenance of cell polarity | 129/7305 | 218/18723 | 1.16e-09 | 2.86e-08 | 129 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPA | SNV | Missense_Mutation | c.238C>T | p.Arg80Cys | p.R80C | P49450 | protein_coding | tolerated(0.05) | benign(0.054) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CENPA | SNV | Missense_Mutation | novel | c.203N>A | p.Ser68Asn | p.S68N | P49450 | protein_coding | deleterious(0.01) | possibly_damaging(0.787) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPA | SNV | Missense_Mutation | novel | c.107N>T | p.Ser36Phe | p.S36F | P49450 | protein_coding | tolerated(0.14) | benign(0.28) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CENPA | SNV | Missense_Mutation | novel | c.205C>T | p.Arg69Cys | p.R69C | P49450 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CENPA | SNV | Missense_Mutation | novel | c.184A>G | p.Ile62Val | p.I62V | P49450 | protein_coding | deleterious(0.04) | benign(0.238) | TCGA-DD-AACH-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CENPA | SNV | Missense_Mutation | novel | c.205N>T | p.Arg69Cys | p.R69C | P49450 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CENPA | SNV | Missense_Mutation | novel | c.206N>T | p.Arg69Leu | p.R69L | P49450 | protein_coding | tolerated(0.06) | benign(0.231) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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