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Gene: CCDC85C |
Gene summary for CCDC85C |
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Gene information | Species | Human | Gene symbol | CCDC85C | Gene ID | 317762 |
Gene name | coiled-coil domain containing 85C | |
Gene Alias | CCDC85C | |
Cytomap | 14q32.2 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A6NKD9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
317762 | CCDC85C | LZE2T | Human | Esophagus | ESCC | 1.03e-02 | 4.57e-01 | 0.082 |
317762 | CCDC85C | LZE4T | Human | Esophagus | ESCC | 4.78e-08 | 3.14e-01 | 0.0811 |
317762 | CCDC85C | LZE5T | Human | Esophagus | ESCC | 2.14e-02 | 4.08e-01 | 0.0514 |
317762 | CCDC85C | LZE20T | Human | Esophagus | ESCC | 2.84e-06 | 1.61e-01 | 0.0662 |
317762 | CCDC85C | LZE24T | Human | Esophagus | ESCC | 7.84e-17 | 4.60e-01 | 0.0596 |
317762 | CCDC85C | P2T-E | Human | Esophagus | ESCC | 1.19e-03 | 4.61e-02 | 0.1177 |
317762 | CCDC85C | P4T-E | Human | Esophagus | ESCC | 6.00e-03 | 1.19e-01 | 0.1323 |
317762 | CCDC85C | P5T-E | Human | Esophagus | ESCC | 5.49e-04 | 5.28e-02 | 0.1327 |
317762 | CCDC85C | P8T-E | Human | Esophagus | ESCC | 2.36e-14 | 2.91e-01 | 0.0889 |
317762 | CCDC85C | P10T-E | Human | Esophagus | ESCC | 4.53e-13 | 2.00e-01 | 0.116 |
317762 | CCDC85C | P11T-E | Human | Esophagus | ESCC | 5.22e-04 | 1.20e-01 | 0.1426 |
317762 | CCDC85C | P12T-E | Human | Esophagus | ESCC | 5.43e-09 | 2.00e-01 | 0.1122 |
317762 | CCDC85C | P15T-E | Human | Esophagus | ESCC | 1.21e-13 | 3.91e-01 | 0.1149 |
317762 | CCDC85C | P16T-E | Human | Esophagus | ESCC | 2.50e-03 | 4.01e-02 | 0.1153 |
317762 | CCDC85C | P17T-E | Human | Esophagus | ESCC | 3.93e-02 | 1.33e-01 | 0.1278 |
317762 | CCDC85C | P20T-E | Human | Esophagus | ESCC | 3.32e-08 | 2.39e-01 | 0.1124 |
317762 | CCDC85C | P21T-E | Human | Esophagus | ESCC | 6.15e-06 | 1.92e-01 | 0.1617 |
317762 | CCDC85C | P22T-E | Human | Esophagus | ESCC | 3.83e-07 | 6.61e-02 | 0.1236 |
317762 | CCDC85C | P24T-E | Human | Esophagus | ESCC | 7.85e-06 | 4.50e-02 | 0.1287 |
317762 | CCDC85C | P26T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.29e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Thyroid | PTC | ![]() |
Thyroid | goiters | ![]() |
Thyroid | ATC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
GO:00219876 | Oral cavity | OSCC | cerebral cortex development | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
GO:00215435 | Oral cavity | OSCC | pallium development | 81/7305 | 169/18723 | 1.11e-02 | 3.76e-02 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC85C | SNV | Missense_Mutation | c.800N>T | p.Ser267Leu | p.S267L | A6NKD9 | protein_coding | deleterious(0.02) | benign(0.289) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC85C | SNV | Missense_Mutation | c.988N>A | p.Pro330Thr | p.P330T | A6NKD9 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CCDC85C | SNV | Missense_Mutation | novel | c.890N>A | p.Arg297His | p.R297H | A6NKD9 | protein_coding | tolerated(0.08) | probably_damaging(0.926) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CCDC85C | SNV | Missense_Mutation | c.889N>T | p.Arg297Cys | p.R297C | A6NKD9 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-D1-A17R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCDC85C | deletion | Frame_Shift_Del | novel | c.1014delN | p.Ser339LeufsTer18 | p.S339Lfs*18 | A6NKD9 | protein_coding | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CCDC85C | SNV | Missense_Mutation | novel | c.19A>G | p.Thr7Ala | p.T7A | A6NKD9 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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